[C+NC+CC] Coupling-Enabled Synthesis of Influenza Neuramidase Inhibitor A-315675
An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.
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Veröffentlicht in: | Organic letters 2012-03, Vol.14 (5), p.1326-1329 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol3002128 |