[C+NC+CC] Coupling-Enabled Synthesis of Influenza Neuramidase Inhibitor A-315675

An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.

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Veröffentlicht in:Organic letters 2012-03, Vol.14 (5), p.1326-1329
Hauptverfasser: Garner, Philip, Weerasinghe, Laksiri, Youngs, Wiley J, Wright, Brian, Wilson, Dean, Jacobs, Dylan
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Sprache:eng
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Zusammenfassung:An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol3002128