Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial–mesenchymaltransition

Background and AimsThe authors have previously isolated a putative oncogene, eukaryotic initiation factor 5A2 (EIF5A2) from 3q26. In this study, EIF5A2 was characterised for its role in colorectal carcinoma (CRC) aggressiveness and underlying molecular mechanisms.MethodsThe expression dynamics of EI...

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Veröffentlicht in:	Gut 2012-04, Vol.61 (4), p.562-575
Hauptverfasser:	Zhu, Wei, Cai, Mu-Yan, Tong, Zhu-Ting, Dong, Sui-Sui, Mai, Shi-Juan, Liao, Yi-Ji, Bian, Xiu-Wu, Lin, Marie C, Kung, Hsiang-Fu, Zeng, Yi-Xin, Guan, Xin-Yuan, Xie, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquisitions & mergers Aggressiveness Animals Biological and medical sciences Biomarkers, Tumor - metabolism Cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology DNA-Binding Proteins - physiology EIF5A2 Epithelial-Mesenchymal Transition - physiology epithelial–mesenchymal transition Eukaryotic Translation Initiation Factor 5A Female Gastroenterology. Liver. Pancreas. Abdomen Genes Genotype & phenotype Histone Deacetylases - biosynthesis Humans Male Medical prognosis Medical sciences Metastasis Mice Mice, SCID MTA1 Neoplasm Grading Neoplasm Invasiveness Neoplasm Proteins - metabolism Neoplasm Proteins - physiology Neoplasm Staging Peptide Initiation Factors - metabolism Peptide Initiation Factors - physiology Prognosis Proteins Real-Time Polymerase Chain Reaction - methods Repressor Proteins - biosynthesis RNA-Binding Proteins - metabolism RNA-Binding Proteins - physiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Studies Trans-Activators Transcription Factors - physiology Tumor Cells, Cultured Tumorigenesis Tumors Up-Regulation - physiology
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Zusammenfassung:	Background and AimsThe authors have previously isolated a putative oncogene, eukaryotic initiation factor 5A2 (EIF5A2) from 3q26. In this study, EIF5A2 was characterised for its role in colorectal carcinoma (CRC) aggressiveness and underlying molecular mechanisms.MethodsThe expression dynamics of EIF5A2 were examined by immunohistochemistry in a cohort of carcinomatous and non-neoplastic colorectal tissues and cells. A series of in-vivo and in-vitro assays was performed to elucidate the function of EIF5A2 in CRC and its underlying mechanisms.ResultsThe overexpression of EIF5A2 was examined by immunohistochemistry in 102/229 (44.5%) CRC patients, and it was significantly correlated with tumour metastasis and determined to be an independent predictor of shortened survival (p
ISSN:	0017-5749 1468-3288
DOI:	10.1136/gutjnl-2011-300207