A General Preparation of Protected Phosphoamino Acids

A General Preparation of Protected Phosphoamino Acids

Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was use...

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Veröffentlicht in:Organic letters 2012-03, Vol.14 (5), p.1206-1209
Hauptverfasser: Petrillo, Daniel E, Mowrey, Dale R, Allwein, Shawn P, Bakale, Roger P
Format: Artikel
Sprache:eng
Schlagworte:
Molecular Structure
Oxidants - chemistry
Peptides - chemistry
Phosphoamino Acids - chemical synthesis
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Zusammenfassung:Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol203332j