Evaluation of HIV Protease Inhibitor Use and the Risk of Sudden Death or Nonhemorrhagic Stroke

Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exp...

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Veröffentlicht in:	The Journal of infectious diseases 2012-02, Vol.205 (4), p.535-539
Hauptverfasser:	Worm, S. W., Kamara, D. A., Reiss, P., Fontas, E., De Wit, S., El-Sadr, W., Monforte, A. D'Arminio, Law, M., Phillips, A., Ryom, L., Dabis, F., Weber, R., Sabin, C., Lundgren, J. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antihypertensives Antivirals Biological and medical sciences Body mass index Cholesterols Death, Sudden - epidemiology Female Fundamental and applied biological sciences. Psychology HIV HIV Infections - complications HIV Infections - drug therapy HIV protease inhibitors HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - adverse effects HIV/AIDS Humans Infectious diseases Male Medical sciences Memory interference Microbiology Middle Aged Miscellaneous Predisposing factors Risk Assessment Stroke - epidemiology Stroke - mortality Strokes Sudden death Virology
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Zusammenfassung:	Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jir788