Synthesis of the Smallest Axially Chiral Molecule by Asymmetric Carbon-Fluorine Bond Activation

Synthesis of the Smallest Axially Chiral Molecule by Asymmetric Carbon-Fluorine Bond Activation

Enantioselect‐DeFluor: Carbon–fluorine bond cleavage by a chiral zirconium complex allows the synthesis of optically active 1,3‐difluoroallene for the first time. Its absolute configuration was established by gas‐phase vibrational circular dichroism spectroscopy (see picture).

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Veröffentlicht in:Angewandte Chemie International Edition 2012-02, Vol.51 (9), p.2218-2220
Hauptverfasser: Kuehnel, Moritz F., Schlöder, Tobias, Riedel, Sebastian, Nieto-Ortega, Belén, Ramírez, Francisco J., López Navarrete, Juan T., Casado, Juan, Lentz, Dieter
Format: Artikel
Sprache:eng
Schlagworte:
Activation
allenes
Asymmetry
Bonding
chirality
Cleavage
CF activation
Dichroism
Optical activity
Spectroscopy
Synthesis
vibrational circular dichroism
Zirconium
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Beschreibung
Zusammenfassung:Enantioselect‐DeFluor: Carbon–fluorine bond cleavage by a chiral zirconium complex allows the synthesis of optically active 1,3‐difluoroallene for the first time. Its absolute configuration was established by gas‐phase vibrational circular dichroism spectroscopy (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201108105