Mu opioid receptor activation modulates Toll like receptor 4 in murine macrophages

Highlight ► The mu opioid receptor exerts a tonic inhibitory effect on the production and expression of TLR4 in murine macrophages.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2012-03, Vol.26 (3), p.480-488
Hauptverfasser:	Franchi, Silvia, Moretti, Sarah, Castelli, Mara, Lattuada, Donatella, Scavullo, Cinzia, Panerai, Alberto E, Sacerdote, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Analgesics, Opioid - pharmacology Animals Cells, Cultured Gene Expression - drug effects Immunosuppressive Agents - pharmacology Macrophage Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Mice MOR Morphine Morphine - pharmacology Naltrexone - pharmacology Opioids Psychiatry Receptors, Opioid, mu - drug effects Receptors, Opioid, mu - immunology Receptors, Opioid, mu - metabolism TLR4 Toll-Like Receptor 4 - drug effects Toll-Like Receptor 4 - immunology Toll-Like Receptor 4 - metabolism
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Beschreibung
Zusammenfassung:	Highlight ► The mu opioid receptor exerts a tonic inhibitory effect on the production and expression of TLR4 in murine macrophages.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2011.12.010