Oxidation-hydroxymethylation-reduction: a one-pot three-step biocatalytic synthesis of optically active α-aryl vicinal diols

A one-pot multi-step approach comprising enzymatic oxidation-hydroxymethylation-reduction enables the synthesis of optically active alpha -aryl vicinal diols with high yields and enantioselectivities. Formaldehyde required for the hydroxymethylation step is enzymatically produced in situ using less...

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Veröffentlicht in:	Green chemistry : an international journal and green chemistry resource : GC 2012, Vol.14 (1), p.94-97
Hauptverfasser:	SHANMUGANATHAN, Saravanakumar, NATALIA, Dessy, GREINER, Lasse, DOMINGUEZ DE MARIA, Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Chemistry Exact sciences and technology Fundamental and applied biological sciences. Psychology Kinetics and mechanisms Methods. Procedures. Technologies Organic chemistry Reactivity and mechanisms
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Beschreibung
Zusammenfassung:	A one-pot multi-step approach comprising enzymatic oxidation-hydroxymethylation-reduction enables the synthesis of optically active alpha -aryl vicinal diols with high yields and enantioselectivities. Formaldehyde required for the hydroxymethylation step is enzymatically produced in situ using less hazardous methanol as substrate.
ISSN:	1463-9262 1463-9270
DOI:	10.1039/c1gc16092c