Hybrid liposomes inhibit growth and invasion of human osteosarcoma cells leading to apoptosis

Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 10mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-02, Vol.22 (4), p.1784-1787
Hauptverfasser:	Kitajima, Hideki, Komizu, Yuji, Ueoka, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Biological and medical sciences Cell Line, Tumor Cell migration Cell Movement - drug effects Dimyristoylphosphatidylcholine - chemistry Dimyristoylphosphatidylcholine - pharmacology Ethers Flow Cytometry Fluorescence fluorescence microscopy Humans Hybrid liposomes Hybrids Inhibitory Concentration 50 Invasion Liposomes Liposomes - chemistry Liposomes - pharmacology Medical sciences Molecular Structure Neoplasm Invasiveness Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma cells Pharmacology. Drug treatments polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Wounds
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Zusammenfassung:	Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 10mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and flow cytometric analyses revealed the induction of apoptosis by HL-n in both cells. It is noteworthy that HL-23 could inhibit the invasion and migration of U-2 OS cells on the basis of matrigel invasion assay and scratch wound assay, respectively.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2011.12.031