Is RORγ a therapeutic target for treating Mycobacterium tuberculosis infections?

Summary A link is hypothesized between inhibition of the retinoic acid receptor-related orphan receptor γ (RORγ) and treatment of Mycobacterium tuberculosis (Mtb) infection. An unexpected overlap was found between inhibitors of both Mtb H37Rv with RORγ in PubChem. Since RORγ is not present in Mtb, a...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2012-01, Vol.92 (1), p.95-99
1. Verfasser:	Baures, Paul W
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol catabolism Gemfibrozil Gemfibrozil - antagonists & inhibitors Humans Immune system function Infectious Disease Macrophages - drug effects Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Pulmonary/Respiratory Receptors, Retinoic Acid - drug effects Retinoic Acid Receptor gamma Retinoic acid receptor-related orphan receptor γ Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - metabolism
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