Is RORγ a therapeutic target for treating Mycobacterium tuberculosis infections?

Summary A link is hypothesized between inhibition of the retinoic acid receptor-related orphan receptor γ (RORγ) and treatment of Mycobacterium tuberculosis (Mtb) infection. An unexpected overlap was found between inhibitors of both Mtb H37Rv with RORγ in PubChem. Since RORγ is not present in Mtb, a...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2012-01, Vol.92 (1), p.95-99
1. Verfasser:	Baures, Paul W
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol catabolism Gemfibrozil Gemfibrozil - antagonists & inhibitors Humans Immune system function Infectious Disease Macrophages - drug effects Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Pulmonary/Respiratory Receptors, Retinoic Acid - drug effects Retinoic Acid Receptor gamma Retinoic acid receptor-related orphan receptor γ Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - metabolism
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Zusammenfassung:	Summary A link is hypothesized between inhibition of the retinoic acid receptor-related orphan receptor γ (RORγ) and treatment of Mycobacterium tuberculosis (Mtb) infection. An unexpected overlap was found between inhibitors of both Mtb H37Rv with RORγ in PubChem. Since RORγ is not present in Mtb, a commonality was reasoned to be cholesterol. Gemfibrozil is a RORγ inhibitor that was inactive against Mtb cells. Yet, gemfibrozil has been shown to inhibit Mtb growth in macrophages, supporting the hypothesis that RORγ inhibitors could show therapeutic benefit in Mtb infection.
ISSN:	1472-9792 1873-281X
DOI:	10.1016/j.tube.2011.11.009