Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer

Cisplatin is an effective anticancer drug used to treat many types of cancer, including non-small cell lung carcinoma (NSCLCs), but development of resistance is the primary impediment in cancer treatment. Insulin-like growth factor-binding protein 7 (IGFBP7) is a secreted tumor suppressor that is in...

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Veröffentlicht in:	Cancer biology & therapy 2012-02, Vol.13 (3), p.148-155
Hauptverfasser:	Okamura, Jun, Huang, Yiping, Moon, David, Brait, Mariana, Chang, Xiaofei, Sook-Kim, Myoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Binding Biology Bioscience Calcium Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Cell Cell Line, Tumor Cisplatin - pharmacology cisplatin resistance Cycle Down-Regulation Drug Resistance, Neoplasm Dual Specificity Phosphatase 6 - genetics Dual Specificity Phosphatase 6 - metabolism Erk Gene Expression Regulation, Neoplastic human xenografts Humans IGFBP7 Insulin-Like Growth Factor Binding Proteins - genetics Insulin-Like Growth Factor Binding Proteins - metabolism Landes Lung Neoplasms - drug therapy Lung Neoplasms - pathology MAP Kinase Signaling System Mice Mice, Nude MKP3 NSCLC Organogenesis Proteins Real-Time Polymerase Chain Reaction Research Paper STAT3 Transcription, Genetic Tumor Burden - drug effects Xenograft Model Antitumor Assays
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