Endothelin-1 promotes cytoplasmic accumulation of RIP140 through a ET(A)-PLCβ-PKCε pathway

The physiological signal activating cytoplasmic accumulation of nuclear receptor interacting protein 140 (RIP140) in adipocytes was unclear. We uncover that endothelin-1 (ET-1) promotes cytoplasmic accumulation of RIP140 in 3T3-L1 adipocytes. We determine ET-1's signal transduction pathway in a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular endocrinology 2012-04, Vol.351 (2), p.176-183
Hauptverfasser:	Ho, Ping-Chih, Tsui, Yao-Chen, Lin, Yi-Wei, Persaud, Shawna D, Wei, Li-Na
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adaptor Proteins, Signal Transducing - metabolism Adipocytes - metabolism Animals Blood Glucose - metabolism Cells, Cultured Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diet, High-Fat Endothelin A Receptor Antagonists Endothelin-1 - antagonists & inhibitors Endothelin-1 - metabolism Endothelin-1 - pharmacology Fatty Liver Insulin Resistance Male Mice Mice, Inbred C57BL Mice, Obese Nuclear Proteins - metabolism Obesity Phenylpropionates - pharmacology Phosphoinositide Phospholipase C - genetics Phosphoinositide Phospholipase C - metabolism Phospholipase C beta - antagonists & inhibitors Phospholipase C beta - metabolism Pyridazines - pharmacology Receptor, Endothelin A - metabolism RNA Interference RNA, Small Cytoplasmic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!