Adrenalectomy stimulates the formation of initial atherosclerotic lesions: Reversal by adrenal transplantation

Highlights ► Adrenalectomy enhances the systemic inflammatory status. ► Adrenalectomy lowers plasma cholesterol and triglyceride levels. ► Adrenal transplantation restores adrenocortical steroid secretion. ► Adrenal-derived steroids protect against development of atherosclerotic lesions.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Atherosclerosis 2012-03, Vol.221 (1), p.76-83
Hauptverfasser:	van der Sluis, Ronald J, van Puijvelde, Gijs H, Van Berkel, Theo J.C, Hoekstra, Menno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Adrenal Glands - metabolism Adrenal Glands - transplantation adrenal medulla Adrenalectomy Adrenalectomy - adverse effects Animals Aortic Diseases - blood Aortic Diseases - etiology Aortic Diseases - genetics Aortic Diseases - immunology Aortic Diseases - pathology Aortic Diseases - prevention & control Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - blood Atherosclerosis - etiology Atherosclerosis - genetics Atherosclerosis - immunology Atherosclerosis - pathology Atherosclerosis - prevention & control Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cardiovascular system chemokines Cholesterol Cholesterol - blood corticosterone Corticosterone - blood Cytokines - metabolism diet Diet, High-Fat Disease Models, Animal glucocorticoid receptors Glucocorticoids - blood Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Inflammation Mediators - metabolism Investigative techniques, diagnostic techniques (general aspects) LDL receptor knockout mice Leukocyte Count leukocytes low density lipoprotein Lymphocyte Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Radiodiagnosis. Nmr imagery. Nmr spectrometry Receptors, LDL - deficiency Receptors, LDL - genetics risk secretion steroid metabolism Steroidogenesis triacylglycerols Triglycerides - blood
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Adrenalectomy enhances the systemic inflammatory status. ► Adrenalectomy lowers plasma cholesterol and triglyceride levels. ► Adrenal transplantation restores adrenocortical steroid secretion. ► Adrenal-derived steroids protect against development of atherosclerotic lesions.
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2011.12.022