Targeting epigenetic mechanisms for pain relief

Highlights ► Epigenetic mechanisms are engaged after injury and in chronic pain states. ► Epigenetic marks are observed after noxious stimulation within nociceptive pathways. ► DNMT and HDAC inhibitors can reduce pain behaviour.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in pharmacology 2012-02, Vol.12 (1), p.35-41
1. Verfasser:	Sandrine M, Geranton
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - therapeutic use Antineoplastic Agents - pharmacology Epigenesis, Genetic - physiology Humans Internal Medicine Learning Medical Education Pain - drug therapy Pain - metabolism Pain Management - methods
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Beschreibung
Zusammenfassung:	Highlights ► Epigenetic mechanisms are engaged after injury and in chronic pain states. ► Epigenetic marks are observed after noxious stimulation within nociceptive pathways. ► DNMT and HDAC inhibitors can reduce pain behaviour.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2011.10.012