Chemokines and cytokines in neuroinflammation leading to neuropathic pain
Highlights ► Chemokine–cytokine network causes neuroinflammation that lead to neuropathic pain. ► Neuroinflammation after injury consists of peripheral and central sensitizations. ► Leukocytes interact with primary neurons and elicit peripheral sensitization. ► Spinal glial cells sensitize secondary...
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| Veröffentlicht in: | Current opinion in pharmacology 2012-02, Vol.12 (1), p.55-61 |
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| creator | Kiguchi, Norikazu Kobayashi, Yuka Kishioka, Shiroh |
| description | Highlights ► Chemokine–cytokine network causes neuroinflammation that lead to neuropathic pain. ► Neuroinflammation after injury consists of peripheral and central sensitizations. ► Leukocytes interact with primary neurons and elicit peripheral sensitization. ► Spinal glial cells sensitize secondary neurons and elicit central sensitization. ► The roles of principal chemokines and cytokines in neuropathic pain were shown. |
| doi_str_mv | 10.1016/j.coph.2011.10.007 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Attention CCL3 protein Central nervous system Chemokines Cytokines Cytokines - genetics Cytokines - metabolism Fractalkine Gene Expression Regulation Humans Inflammation Inflammation - metabolism Inflammation - pathology Injuries Interleukin 1 Internal Medicine Medical Education Monocyte chemoattractant protein 1 Neuralgia - metabolism Neuralgia - pathology Neuropathy Reviews Signal Transduction |
| title | Chemokines and cytokines in neuroinflammation leading to neuropathic pain |
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