Chemokines and cytokines in neuroinflammation leading to neuropathic pain

Highlights ► Chemokine–cytokine network causes neuroinflammation that lead to neuropathic pain. ► Neuroinflammation after injury consists of peripheral and central sensitizations. ► Leukocytes interact with primary neurons and elicit peripheral sensitization. ► Spinal glial cells sensitize secondary...

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Veröffentlicht in:	Current opinion in pharmacology 2012-02, Vol.12 (1), p.55-61
Hauptverfasser:	Kiguchi, Norikazu, Kobayashi, Yuka, Kishioka, Shiroh
Format:	Artikel
Sprache:	eng
Schlagworte:	Attention CCL3 protein Central nervous system Chemokines Cytokines Cytokines - genetics Cytokines - metabolism Fractalkine Gene Expression Regulation Humans Inflammation Inflammation - metabolism Inflammation - pathology Injuries Interleukin 1 Internal Medicine Medical Education Monocyte chemoattractant protein 1 Neuralgia - metabolism Neuralgia - pathology Neuropathy Reviews Signal Transduction
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Beschreibung
Zusammenfassung:	Highlights ► Chemokine–cytokine network causes neuroinflammation that lead to neuropathic pain. ► Neuroinflammation after injury consists of peripheral and central sensitizations. ► Leukocytes interact with primary neurons and elicit peripheral sensitization. ► Spinal glial cells sensitize secondary neurons and elicit central sensitization. ► The roles of principal chemokines and cytokines in neuropathic pain were shown.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2011.10.007