SDF-1/CXCL12: Its role in spinal cord injury

The chemokine stromal cell-derived factor 1 (SDF-1/CXCL12), is not only the most ancient, but also one of the most potent chemotactic factors. Orchestrating the migration of cells as well as promoting axon outgrowth in the presence of myelin inhibitors, SDF-1 is fundamental to central nervous system...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2012-03, Vol.44 (3), p.452-456
Hauptverfasser:	Jaerve, Anne, Bosse, Frank, Müller, Hans Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	animal injuries Animals Axon outgrowth axons Axons - physiology cell biology Cell Movement - genetics Central nervous system trauma chemoattractants Chemokine Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism chemokines Chemotaxis - genetics CXCR4 CXCR7 homeostasis Humans Molecular Targeted Therapy myelin sheath neurodevelopment spinal cord Spinal Cord Injuries - drug therapy Spinal Cord Injuries - genetics Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology sprouting
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Beschreibung
Zusammenfassung:	The chemokine stromal cell-derived factor 1 (SDF-1/CXCL12), is not only the most ancient, but also one of the most potent chemotactic factors. Orchestrating the migration of cells as well as promoting axon outgrowth in the presence of myelin inhibitors, SDF-1 is fundamental to central nervous system development, homeostasis and traumatic injury. SDF-1 attracts endogenous stem/precursor cells and immune cells to the injury site and, upon local infusion, enhances axonal sprouting following spinal cord injury. Together these features make SDF-1 a very exciting molecule for spinal cord repair.
ISSN:	1357-2725 1878-5875
DOI:	10.1016/j.biocel.2011.11.023