ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer

Purpose Cathepsin and plasmin may favor cancer cell invasion degrading extracellular matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variatio...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2012-03, Vol.138 (3), p.501-511
Hauptverfasser:	Mazzoccoli, Gianluigi, Pazienza, Valerio, Panza, Anna, Valvano, Maria Rosa, Benegiamo, Giorgia, Vinciguerra, Manlio, Andriulli, Angelo, Piepoli, Ada
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents ARNTL Transcription Factors - analysis ARNTL Transcription Factors - genetics Biological and medical sciences Biomarkers Biomarkers, Tumor - analysis Cancer Research Cell adhesion & migration Cell Line, Tumor Colorectal cancer Colorectal Neoplasms - chemistry Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Hematology Humans Internal Medicine Lymphatic Metastasis Male Medical sciences Medicine Medicine & Public Health Metastasis Microsatellite Instability Middle Aged Neoplasm Grading Neoplasm Invasiveness Neoplasm Staging Oncology Original Paper Pharmacology. Drug treatments Plasminogen Activator Inhibitor 1 - analysis Plasminogen Activator Inhibitor 1 - blood Plasminogen Activator Inhibitor 1 - genetics Predictive Value of Tests Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors
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Zusammenfassung:	Purpose Cathepsin and plasmin may favor cancer cell invasion degrading extracellular matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variation in circulating PAI-1 levels. Methods We evaluated ARNTL2 and SERPINE1 expression in 50 colorectal cancer specimens and adjacent normal tissue and in colon cancer cell lines. Results We found up-regulation of ARNTL2 ( P = 0.004) and SERPINE1 ( P = 0.002) in tumor tissue. A statistically significant association was found between high ARNTL2 mRNA levels and vascular invasion ( P
ISSN:	0171-5216 1432-1335
DOI:	10.1007/s00432-011-1126-6