A New Direction in CH Alkenylation: Silanol as a Helping Hand

A New Direction in CH Alkenylation: Silanol as a Helping Hand

Director's cut: Not only conventional alcohols but also silanols can act as directing groups in oxidative palladium(II)‐catalyzed CH alkenylations. The silicon‐tethered hydroxy groups are “traceless”, thereby facilitating the regioselective CH activation of toluene derivitives as well as phen...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-02, Vol.51 (8), p.1763-1765
Hauptverfasser: Mewald, Marius, Schiffner, Julia A., Oestreich, Martin
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Alcohols
alkenylation
cross-coupling
CH activation
directing groups
Phenols
silicon
Toluene
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Zusammenfassung:Director's cut: Not only conventional alcohols but also silanols can act as directing groups in oxidative palladium(II)‐catalyzed CH alkenylations. The silicon‐tethered hydroxy groups are “traceless”, thereby facilitating the regioselective CH activation of toluene derivitives as well as phenols (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201107859