Prediction of selective fetal growth restriction and twin-to-twin transfusion syndrome in monochorionic twins

Please cite this paper as: Memmo A, Dias T, Mahsud‐Dornan S, Papageorghiou A, Bhide A, Thilaganathan B. Prediction of selective fetal growth restriction and twin‐to‐twin transfusion syndrome in monochorionic twins. BJOG 2012;119:417–421. Objective To study the correlation of discrepancy between crown–rump length (CRL) and nuchal translucency (NT) in monochorionic twins at 11–14 weeks of gestation and subsequent development of twin‐to‐twin transfusion syndrome (TTTS) and selective fetal growth restriction (sFGR). Design Retrospective cohort study. Setting Tertiary‐care Fetal Medicine Unit, London. Sample Monochorionic twin pregnancies with known outcome. Methods Inter‐twin discrepancy was calculated as a percentage of the larger CRL and smaller NT and compared among those developing TTTS, those with sFGR and those with normal outcome. Receiver operating characteristic (ROC) curves were constructed to evaluate the performance of inter‐twin discrepancy in prediction of sFGR and TTTS. Main outcome measures Development of TTTS and sFGR. Results A total of 242 monochorionic twin pregnancies were studied (102 TTTS, 36 sFGR and 104 controls). The median CRL discrepancy in the sFGR group (11.9%) was significantly higher (P