Prognostic Risk Factor Evaluation in Patients With Relapsed or Refractory Multiple Myeloma Receiving Lenalidomide Treatment: Analysis of Renal Function by eGFR and of Additional Comorbidities by Comorbidity Appraisal

Prognostic Risk Factor Evaluation in Patients With Relapsed or Refractory Multiple Myeloma Receiving Lenalidomide Treatment: Analysis of Renal Function by eGFR and of Additional Comorbidities by Comorbidity Appraisal

Micro-Abstract In patients with MM, RI remains associated with a poor prognosis, especially if it occurs at the time of MM diagnosis. The impact of various comorbidities in the era of novel agents is unknown and needs further investigation. We evaluated the safety, efficacy, and outcome of lenalidom...

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Veröffentlicht in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2012-02, Vol.12 (1), p.38-48
Hauptverfasser: Kleber, Martina, Ihorst, Gabriele, Udi, Josefina, Koch, Bernd, Wäsch, Ralph, Engelhardt, Monika
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Comorbidities
Comorbidity
Depression - chemically induced
Dexamethasone - administration & dosage
Dexamethasone - adverse effects
Drug Administration Schedule
Drug Resistance, Neoplasm
Exanthema - chemically induced
Female
Glomerular Filtration Rate - drug effects
Hematology, Oncology and Palliative Medicine
Humans
Kaplan-Meier Estimate
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - physiopathology
Lenalidomide
Male
Middle Aged
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - epidemiology
Neutropenia - chemically induced
Outcome
Prognosis
Recurrence
Risk Factors
Side effects
Thalidomide - administration & dosage
Thalidomide - adverse effects
Thalidomide - analogs & derivatives
Thalidomide - therapeutic use
Treatment Outcome
Tremor - chemically induced
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Zusammenfassung:Micro-Abstract In patients with MM, RI remains associated with a poor prognosis, especially if it occurs at the time of MM diagnosis. The impact of various comorbidities in the era of novel agents is unknown and needs further investigation. We evaluated the safety, efficacy, and outcome of lenalidomide treatment in patients with relapsed/refractory MM and various comorbidities, including RI.
ISSN:2152-2650
2152-2669
DOI:10.1016/j.clml.2011.09.216