Towards a driver fatigue test based on the saccadic main sequence: A partial validation by subjective report data

► Different levels of mental fatigue were induced. ► SIRCA driving simulator was used. ► Saccadic parameters were recorded before, during, and after 2-h of driving. ► Main sequence parameters revealed sensitivity to changes in drivers’ vigilance state. ► Requirements for the development of new driver-fatigue screening tools are discussed. Developing a valid measurement of mental fatigue remains a big challenge and would be beneficial for various application areas, such as the improvement of road traffic safety. In the present study we examined influences of mental fatigue on the dynamics of saccadic eye movements. Based on previous findings, we propose that among amplitude and duration of saccades, the peak velocity of saccadic eye movements is particularly sensitive to changes in mental fatigue. Ten participants completed a fixation task before and after 2 h of driving in a virtual simulation environment as well as after a rest break of fifteen minutes. Driving and rest break were assumed to directly influence the level of mental fatigue and were evaluated using subjective ratings and eye movement indices. According to the subjective ratings, mental fatigue was highest after driving but decreased after the rest break. The peak velocity of saccadic eye movements decreased after driving while the duration of saccades increased, but no effects of the rest break were observed in the saccade parameters. We conclude that saccadic eye movement parameters—particularly the peak velocity—are sensitive indicators for mental fatigue. According to these findings, the peak velocity analysis represents a valid on-line measure for the detection of mental fatigue, providing the basis for the development of new vigilance screening tools to prevent accidents in several application domains.