Xenotropic murine leukaemia virus-related virus (XMRV) does not cause chronic fatigue

The xenotropic murine leukaemia virus-related virus (XMRV), a gammaretrovirus, was discovered in prostate cancer tumours by Virochip technology in 2006. It was subsequently detected in chronic fatigue patients in 2009. The association between XMRV and chronic fatigue has proved to be controversial....

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2011-11, Vol.19 (11), p.525-529
Hauptverfasser:	Robinson, Mark J, Erlwein, Otto, McClure, Myra O
Format:	Artikel
Sprache:	eng
Schlagworte:	Fatigue Syndrome, Chronic - etiology Fatigue Syndrome, Chronic - virology Humans Internal Medicine leukemia mice pathogens patients prostatic neoplasms viruses Xenotropic murine leukemia virus-related virus - genetics Xenotropic murine leukemia virus-related virus - isolation & purification Xenotropic murine leukemia virus-related virus - physiology
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Zusammenfassung:	The xenotropic murine leukaemia virus-related virus (XMRV), a gammaretrovirus, was discovered in prostate cancer tumours by Virochip technology in 2006. It was subsequently detected in chronic fatigue patients in 2009. The association between XMRV and chronic fatigue has proved to be controversial. No study has confirmed these findings and many have refuted them. Here, we present the evidence for our contention that XMRV is not a human pathogen.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2011.08.005