Changes of Positron Emission Tomography in Newborn Infants at Different Gestational Ages, and Neonatal Hypoxic-Ischemic Encephalopathy
Abstract Cerebral glucose metabolism was measured by18 F-fluorodeoxyglucose position emission tomography in infants at different gestational ages and with neonatal hypoxic-ischemic encephalopathy. Thirty-six preterm and term infants at different gestational ages without brain injury were divided int...
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| Veröffentlicht in: | Pediatric neurology 2012-02, Vol.46 (2), p.116-123 |
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| container_title | Pediatric neurology |
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| creator | Shi, Yuan, MD, PhD Zhao, Jin-Ning, MD Liu, Lei, RN Hu, Zhang-Xue, MD Tang, Shi-Fang, MD Chen, Long, MD Jin, Rong-Bin, MD, PhD |
| description | Abstract Cerebral glucose metabolism was measured by18 F-fluorodeoxyglucose position emission tomography in infants at different gestational ages and with neonatal hypoxic-ischemic encephalopathy. Thirty-six preterm and term infants at different gestational ages without brain injury were divided into four subgroups: ≤32 weeks (n = 4), 33-34 weeks (n = 5), 35-36 weeks (n = 12), and ≥37 weeks (n = 15). Twenty-four newborn infants with hypoxic-ischemic encephalopathy were divided into three subgroups: mild (n = 13), moderate (n = 7), and severe (n = 4). Cerebral glucose metabolism manifested a trend toward increase, and the structure of cranial18 F-fluorodeoxyglucose positron emission tomography images became clear with increased gestational age, especially at ≥37 weeks. Uptakes of18 F-fluorodeoxyglucose in the ≥37-week group were significantly higher than in the ≤32-week group (P < 0.01). Cerebral glucose metabolism changed significantly in neonatal hypoxic-ischemic encephalopathy, and was either unbalanced bilaterally or relatively low at all sites. Moreover, uptakes of18 F-fluorodeoxyglucose were significantly lower in severe than in mild and medium hypoxic-ischemic encephalopathy ( P < 0.05). Cerebral glucose metabolism, as measured by18 F-fluorodeoxyglucose positron emission tomography, may prove useful for estimating brain development and injury in newborn infants, and its clinical values need further investigation. |
| doi_str_mv | 10.1016/j.pediatrneurol.2011.11.005 |
| format | Article |
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Thirty-six preterm and term infants at different gestational ages without brain injury were divided into four subgroups: ≤32 weeks (n = 4), 33-34 weeks (n = 5), 35-36 weeks (n = 12), and ≥37 weeks (n = 15). Twenty-four newborn infants with hypoxic-ischemic encephalopathy were divided into three subgroups: mild (n = 13), moderate (n = 7), and severe (n = 4). Cerebral glucose metabolism manifested a trend toward increase, and the structure of cranial18 F-fluorodeoxyglucose positron emission tomography images became clear with increased gestational age, especially at ≥37 weeks. Uptakes of18 F-fluorodeoxyglucose in the ≥37-week group were significantly higher than in the ≤32-week group (P < 0.01). Cerebral glucose metabolism changed significantly in neonatal hypoxic-ischemic encephalopathy, and was either unbalanced bilaterally or relatively low at all sites. Moreover, uptakes of18 F-fluorodeoxyglucose were significantly lower in severe than in mild and medium hypoxic-ischemic encephalopathy ( P < 0.05). Cerebral glucose metabolism, as measured by18 F-fluorodeoxyglucose positron emission tomography, may prove useful for estimating brain development and injury in newborn infants, and its clinical values need further investigation.</description><identifier>ISSN: 0887-8994</identifier><identifier>EISSN: 1873-5150</identifier><identifier>DOI: 10.1016/j.pediatrneurol.2011.11.005</identifier><identifier>PMID: 22264707</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Asphyxia Neonatorum - diagnostic imaging ; Asphyxia Neonatorum - metabolism ; Biological and medical sciences ; Brain - diagnostic imaging ; Brain - metabolism ; Brain Mapping ; Female ; Gestational Age ; Humans ; Hypoxia-Ischemia, Brain - diagnostic imaging ; Hypoxia-Ischemia, Brain - metabolism ; Infant, Newborn ; Infant, Premature ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Nervous system ; Neurology ; Pediatrics ; Radionuclide Imaging ; Radionuclide investigations</subject><ispartof>Pediatric neurology, 2012-02, Vol.46 (2), p.116-123</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-687db2b9834f74883155bbe5e540571940911588e2b346d31c82ca7cc97327993</citedby><cites>FETCH-LOGICAL-c499t-687db2b9834f74883155bbe5e540571940911588e2b346d31c82ca7cc97327993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pediatrneurol.2011.11.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25610441$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22264707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Yuan, MD, PhD</creatorcontrib><creatorcontrib>Zhao, Jin-Ning, MD</creatorcontrib><creatorcontrib>Liu, Lei, RN</creatorcontrib><creatorcontrib>Hu, Zhang-Xue, MD</creatorcontrib><creatorcontrib>Tang, Shi-Fang, MD</creatorcontrib><creatorcontrib>Chen, Long, MD</creatorcontrib><creatorcontrib>Jin, Rong-Bin, MD, PhD</creatorcontrib><title>Changes of Positron Emission Tomography in Newborn Infants at Different Gestational Ages, and Neonatal Hypoxic-Ischemic Encephalopathy</title><title>Pediatric neurology</title><addtitle>Pediatr Neurol</addtitle><description>Abstract Cerebral glucose metabolism was measured by18 F-fluorodeoxyglucose position emission tomography in infants at different gestational ages and with neonatal hypoxic-ischemic encephalopathy. Thirty-six preterm and term infants at different gestational ages without brain injury were divided into four subgroups: ≤32 weeks (n = 4), 33-34 weeks (n = 5), 35-36 weeks (n = 12), and ≥37 weeks (n = 15). Twenty-four newborn infants with hypoxic-ischemic encephalopathy were divided into three subgroups: mild (n = 13), moderate (n = 7), and severe (n = 4). Cerebral glucose metabolism manifested a trend toward increase, and the structure of cranial18 F-fluorodeoxyglucose positron emission tomography images became clear with increased gestational age, especially at ≥37 weeks. Uptakes of18 F-fluorodeoxyglucose in the ≥37-week group were significantly higher than in the ≤32-week group (P < 0.01). Cerebral glucose metabolism changed significantly in neonatal hypoxic-ischemic encephalopathy, and was either unbalanced bilaterally or relatively low at all sites. Moreover, uptakes of18 F-fluorodeoxyglucose were significantly lower in severe than in mild and medium hypoxic-ischemic encephalopathy ( P < 0.05). Cerebral glucose metabolism, as measured by18 F-fluorodeoxyglucose positron emission tomography, may prove useful for estimating brain development and injury in newborn infants, and its clinical values need further investigation.</description><subject>Asphyxia Neonatorum - diagnostic imaging</subject><subject>Asphyxia Neonatorum - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain Mapping</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Hypoxia-Ischemia, Brain - diagnostic imaging</subject><subject>Hypoxia-Ischemia, Brain - metabolism</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Pediatrics</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><issn>0887-8994</issn><issn>1873-5150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkmGLEzEQhhdRvHr6FyQg4he3JtlkkyAIR613hUMFz88hm529pm6TNUnV_gF_tymtin5RCCQMzzszmXeq6gnBc4JJ-2Izn6B3JkcPuxjGOcWEzMvBmN-pZkSKpuaE47vVDEspaqkUO6sepLTBhVCU3a_OKKUtE1jMqu-LtfG3kFAY0PuQXI7Bo-XWpeTK4yZsw20003qPnEdv4WsXokcrPxifEzIZvXbDABF8RpeQsslFZEZ0URI-R8b3RVICuYSu9lP45my9SnYNW2fR0luY1mYMk8nr_cPq3mDGBI9O93n18c3yZnFVX7-7XC0urmvLlMp1K0Xf0U7Jhg2CSdkQzrsOOHCGuSCKYUUIlxJo17C2b4iV1BphrRINFUo159WzY94phs-70rIuX7UwjsZD2CWtKBaq5Uz-mySCC8kYLuTLI2ljSCnCoKfotibuNcH64Jje6D8c0wfHdDnFj6J-fKqz67bQ_9L-tKgAT0-ASdaMQzTeuvSb4y3BjJHCLY8clPl9cRB1sg7KlHsXwWbdB_efDb36K48dnXel9CfYQ9qEXSweJ010ohrrD4clO-wYIRiztpXND6130Zk</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Shi, Yuan, MD, PhD</creator><creator>Zhao, Jin-Ning, MD</creator><creator>Liu, Lei, RN</creator><creator>Hu, Zhang-Xue, MD</creator><creator>Tang, Shi-Fang, MD</creator><creator>Chen, Long, MD</creator><creator>Jin, Rong-Bin, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20120201</creationdate><title>Changes of Positron Emission Tomography in Newborn Infants at Different Gestational Ages, and Neonatal Hypoxic-Ischemic Encephalopathy</title><author>Shi, Yuan, MD, PhD ; Zhao, Jin-Ning, MD ; Liu, Lei, RN ; Hu, Zhang-Xue, MD ; Tang, Shi-Fang, MD ; Chen, Long, MD ; Jin, Rong-Bin, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-687db2b9834f74883155bbe5e540571940911588e2b346d31c82ca7cc97327993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Asphyxia Neonatorum - diagnostic imaging</topic><topic>Asphyxia Neonatorum - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain Mapping</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Hypoxia-Ischemia, Brain - diagnostic imaging</topic><topic>Hypoxia-Ischemia, Brain - metabolism</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Pediatrics</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Yuan, MD, PhD</creatorcontrib><creatorcontrib>Zhao, Jin-Ning, MD</creatorcontrib><creatorcontrib>Liu, Lei, RN</creatorcontrib><creatorcontrib>Hu, Zhang-Xue, MD</creatorcontrib><creatorcontrib>Tang, Shi-Fang, MD</creatorcontrib><creatorcontrib>Chen, Long, MD</creatorcontrib><creatorcontrib>Jin, Rong-Bin, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Pediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Yuan, MD, PhD</au><au>Zhao, Jin-Ning, MD</au><au>Liu, Lei, RN</au><au>Hu, Zhang-Xue, MD</au><au>Tang, Shi-Fang, MD</au><au>Chen, Long, MD</au><au>Jin, Rong-Bin, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes of Positron Emission Tomography in Newborn Infants at Different Gestational Ages, and Neonatal Hypoxic-Ischemic Encephalopathy</atitle><jtitle>Pediatric neurology</jtitle><addtitle>Pediatr Neurol</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>46</volume><issue>2</issue><spage>116</spage><epage>123</epage><pages>116-123</pages><issn>0887-8994</issn><eissn>1873-5150</eissn><abstract>Abstract Cerebral glucose metabolism was measured by18 F-fluorodeoxyglucose position emission tomography in infants at different gestational ages and with neonatal hypoxic-ischemic encephalopathy. Thirty-six preterm and term infants at different gestational ages without brain injury were divided into four subgroups: ≤32 weeks (n = 4), 33-34 weeks (n = 5), 35-36 weeks (n = 12), and ≥37 weeks (n = 15). Twenty-four newborn infants with hypoxic-ischemic encephalopathy were divided into three subgroups: mild (n = 13), moderate (n = 7), and severe (n = 4). Cerebral glucose metabolism manifested a trend toward increase, and the structure of cranial18 F-fluorodeoxyglucose positron emission tomography images became clear with increased gestational age, especially at ≥37 weeks. Uptakes of18 F-fluorodeoxyglucose in the ≥37-week group were significantly higher than in the ≤32-week group (P < 0.01). Cerebral glucose metabolism changed significantly in neonatal hypoxic-ischemic encephalopathy, and was either unbalanced bilaterally or relatively low at all sites. Moreover, uptakes of18 F-fluorodeoxyglucose were significantly lower in severe than in mild and medium hypoxic-ischemic encephalopathy ( P < 0.05). Cerebral glucose metabolism, as measured by18 F-fluorodeoxyglucose positron emission tomography, may prove useful for estimating brain development and injury in newborn infants, and its clinical values need further investigation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22264707</pmid><doi>10.1016/j.pediatrneurol.2011.11.005</doi><tpages>8</tpages></addata></record> |
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| subjects | Asphyxia Neonatorum - diagnostic imaging Asphyxia Neonatorum - metabolism Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Brain Mapping Female Gestational Age Humans Hypoxia-Ischemia, Brain - diagnostic imaging Hypoxia-Ischemia, Brain - metabolism Infant, Newborn Infant, Premature Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Nervous system Neurology Pediatrics Radionuclide Imaging Radionuclide investigations |
| title | Changes of Positron Emission Tomography in Newborn Infants at Different Gestational Ages, and Neonatal Hypoxic-Ischemic Encephalopathy |
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