Changes of Positron Emission Tomography in Newborn Infants at Different Gestational Ages, and Neonatal Hypoxic-Ischemic Encephalopathy

Abstract Cerebral glucose metabolism was measured by18 F-fluorodeoxyglucose position emission tomography in infants at different gestational ages and with neonatal hypoxic-ischemic encephalopathy. Thirty-six preterm and term infants at different gestational ages without brain injury were divided int...

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Veröffentlicht in:Pediatric neurology 2012-02, Vol.46 (2), p.116-123
Hauptverfasser: Shi, Yuan, MD, PhD, Zhao, Jin-Ning, MD, Liu, Lei, RN, Hu, Zhang-Xue, MD, Tang, Shi-Fang, MD, Chen, Long, MD, Jin, Rong-Bin, MD, PhD
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Sprache:eng
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Zusammenfassung:Abstract Cerebral glucose metabolism was measured by18 F-fluorodeoxyglucose position emission tomography in infants at different gestational ages and with neonatal hypoxic-ischemic encephalopathy. Thirty-six preterm and term infants at different gestational ages without brain injury were divided into four subgroups: ≤32 weeks (n = 4), 33-34 weeks (n = 5), 35-36 weeks (n = 12), and ≥37 weeks (n = 15). Twenty-four newborn infants with hypoxic-ischemic encephalopathy were divided into three subgroups: mild (n = 13), moderate (n = 7), and severe (n = 4). Cerebral glucose metabolism manifested a trend toward increase, and the structure of cranial18 F-fluorodeoxyglucose positron emission tomography images became clear with increased gestational age, especially at ≥37 weeks. Uptakes of18 F-fluorodeoxyglucose in the ≥37-week group were significantly higher than in the ≤32-week group (P  < 0.01). Cerebral glucose metabolism changed significantly in neonatal hypoxic-ischemic encephalopathy, and was either unbalanced bilaterally or relatively low at all sites. Moreover, uptakes of18 F-fluorodeoxyglucose were significantly lower in severe than in mild and medium hypoxic-ischemic encephalopathy ( P < 0.05). Cerebral glucose metabolism, as measured by18 F-fluorodeoxyglucose positron emission tomography, may prove useful for estimating brain development and injury in newborn infants, and its clinical values need further investigation.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2011.11.005