8:2 fluorotelomer alcohol: A one-day nose-only inhalation toxicokinetic study in the Sprague-Dawley rat with application to risk assessment
Highlights ► 8:2 FTOH inhalation exposure and metabolism were investigated in rats. ► The parent 8:2 FTOH showed rapid uptake and clearance from the plasma. ► Metabolites were very low and similar to those in plasma following oral dosing. ► They consisted mainly of 7:3 Acid, 8:2 FTCA, PFOA and PFNA....
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| Veröffentlicht in: | Toxicology (Amsterdam) 2012-01, Vol.291 (1-3), p.122-132 |
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| container_title | Toxicology (Amsterdam) |
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| creator | Himmelstein, Matthew W Serex, Tessa L Buck, Robert C Weinberg, Jeffrey T Mawn, Michael P Russell, Mark H |
| description | Highlights ► 8:2 FTOH inhalation exposure and metabolism were investigated in rats. ► The parent 8:2 FTOH showed rapid uptake and clearance from the plasma. ► Metabolites were very low and similar to those in plasma following oral dosing. ► They consisted mainly of 7:3 Acid, 8:2 FTCA, PFOA and PFNA. ► Typical 8:2 FTOH air exposures do not pose toxicity risk for humans. |
| doi_str_mv | 10.1016/j.tox.2011.11.005 |
| format | Article |
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| subjects | 8:2 FTOH Administration, Inhalation air Air - analysis alcohols Algorithms Animals Area Under Curve Atmosphere Exposure Chambers Biological and medical sciences Biotransformation blood Body Weight - drug effects breathing Data Interpretation, Statistical Dose-Response Relationship, Drug Emergency Environmental Pollutants - toxicity Exposure Female Humans Hydrocarbons, Fluorinated - administration & dosage Hydrocarbons, Fluorinated - pharmacokinetics Hydrocarbons, Fluorinated - toxicity Indicators and Reagents Inhalation Inhalation Exposure Male Medical sciences Metabolism metabolites Models, Statistical necrosis Occupational Exposure - adverse effects Oral dose Rats Rats, Sprague-Dawley Risk Assessment Sex Characteristics toxicity Toxicology |
| title | 8:2 fluorotelomer alcohol: A one-day nose-only inhalation toxicokinetic study in the Sprague-Dawley rat with application to risk assessment |
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