8:2 fluorotelomer alcohol: A one-day nose-only inhalation toxicokinetic study in the Sprague-Dawley rat with application to risk assessment

8:2 fluorotelomer alcohol: A one-day nose-only inhalation toxicokinetic study in the Sprague-Dawley rat with application to risk assessment

Highlights ► 8:2 FTOH inhalation exposure and metabolism were investigated in rats. ► The parent 8:2 FTOH showed rapid uptake and clearance from the plasma. ► Metabolites were very low and similar to those in plasma following oral dosing. ► They consisted mainly of 7:3 Acid, 8:2 FTCA, PFOA and PFNA....

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Veröffentlicht in:Toxicology (Amsterdam) 2012-01, Vol.291 (1-3), p.122-132
Hauptverfasser: Himmelstein, Matthew W, Serex, Tessa L, Buck, Robert C, Weinberg, Jeffrey T, Mawn, Michael P, Russell, Mark H
Format: Artikel
Sprache:eng
Schlagworte:
8:2 FTOH
Administration, Inhalation
air
Air - analysis
alcohols
Algorithms
Animals
Area Under Curve
Atmosphere Exposure Chambers
Biological and medical sciences
Biotransformation
blood
Body Weight - drug effects
breathing
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Emergency
Environmental Pollutants - toxicity
Exposure
Female
Humans
Hydrocarbons, Fluorinated - administration & dosage
Hydrocarbons, Fluorinated - pharmacokinetics
Hydrocarbons, Fluorinated - toxicity
Indicators and Reagents
Inhalation
Inhalation Exposure
Male
Medical sciences
Metabolism
metabolites
Models, Statistical
necrosis
Occupational Exposure - adverse effects
Oral dose
Rats
Rats, Sprague-Dawley
Risk Assessment
Sex Characteristics
toxicity
Toxicology
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Beschreibung
Zusammenfassung:Highlights ► 8:2 FTOH inhalation exposure and metabolism were investigated in rats. ► The parent 8:2 FTOH showed rapid uptake and clearance from the plasma. ► Metabolites were very low and similar to those in plasma following oral dosing. ► They consisted mainly of 7:3 Acid, 8:2 FTCA, PFOA and PFNA. ► Typical 8:2 FTOH air exposures do not pose toxicity risk for humans.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2011.11.005