Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD
BACKGROUND Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age. METHODS A pr...
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| Veröffentlicht in: | Human reproduction (Oxford) 2012-01, Vol.27 (1), p.288-293 |
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| container_title | Human reproduction (Oxford) |
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| creator | Desmyttere, S. De Rycke, M. Staessen, C. Liebaers, I. De Schrijver, F. Verpoest, W. Haentjens, P. Bonduelle, Maryse |
| description | BACKGROUND
Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age.
METHODS
A prospective comparative follow-up study of children born after PGD and children born after ICSI by collecting written reports and performing a physical examination at 2 months was performed. Auxological data at birth and physical findings up to 2 months of age were compared for 995 children consecutively live born after embryo biopsy (1994–2009) and for a control group of 1507 children born after ICSI with embryo transfer on Day 5.
RESULTS
No differences regarding mean term, prematurity (term |
| doi_str_mv | 10.1093/humrep/der360 |
| format | Article |
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Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age.
METHODS
A prospective comparative follow-up study of children born after PGD and children born after ICSI by collecting written reports and performing a physical examination at 2 months was performed. Auxological data at birth and physical findings up to 2 months of age were compared for 995 children consecutively live born after embryo biopsy (1994–2009) and for a control group of 1507 children born after ICSI with embryo transfer on Day 5.
RESULTS
No differences regarding mean term, prematurity (term <32 w and <37 w), mean birthweight, very low birthweight (<1500 g), perinatal death, major malformations and neonatal hospitalizations in singletons and multiples born following PGD versus ICSI were observed. Compared with ICSI, fewer multiples born following PGD presented a low birthweight (<2500 g) (P = 0.005).
CONCLUSIONS
Embryo biopsy for PGD does not introduce extra risk to the overall medical condition of newborn children. Multiples born following embryo biopsy appear to be at lower risk for low birthweight compared with multiples born following ICSI.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/der360</identifier><identifier>PMID: 22048989</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Biopsy - adverse effects ; Biopsy - methods ; Birth Weight ; Female ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Infant ; Infant, Newborn ; Male ; Medical sciences ; Multivariate Analysis ; Pregnancy ; Pregnancy Outcome ; Preimplantation Diagnosis - adverse effects ; Preimplantation Diagnosis - methods ; Prospective Studies ; Risk ; Sperm Injections, Intracytoplasmic - methods</subject><ispartof>Human reproduction (Oxford), 2012-01, Vol.27 (1), p.288-293</ispartof><rights>The Author 2011. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-761cce25aef9a7c1a6a758ce62cef81f570003ef3ee7abbd027084543e24d2183</citedby><cites>FETCH-LOGICAL-c426t-761cce25aef9a7c1a6a758ce62cef81f570003ef3ee7abbd027084543e24d2183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25974659$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22048989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Desmyttere, S.</creatorcontrib><creatorcontrib>De Rycke, M.</creatorcontrib><creatorcontrib>Staessen, C.</creatorcontrib><creatorcontrib>Liebaers, I.</creatorcontrib><creatorcontrib>De Schrijver, F.</creatorcontrib><creatorcontrib>Verpoest, W.</creatorcontrib><creatorcontrib>Haentjens, P.</creatorcontrib><creatorcontrib>Bonduelle, Maryse</creatorcontrib><title>Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>BACKGROUND
Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age.
METHODS
A prospective comparative follow-up study of children born after PGD and children born after ICSI by collecting written reports and performing a physical examination at 2 months was performed. Auxological data at birth and physical findings up to 2 months of age were compared for 995 children consecutively live born after embryo biopsy (1994–2009) and for a control group of 1507 children born after ICSI with embryo transfer on Day 5.
RESULTS
No differences regarding mean term, prematurity (term <32 w and <37 w), mean birthweight, very low birthweight (<1500 g), perinatal death, major malformations and neonatal hospitalizations in singletons and multiples born following PGD versus ICSI were observed. Compared with ICSI, fewer multiples born following PGD presented a low birthweight (<2500 g) (P = 0.005).
CONCLUSIONS
Embryo biopsy for PGD does not introduce extra risk to the overall medical condition of newborn children. Multiples born following embryo biopsy appear to be at lower risk for low birthweight compared with multiples born following ICSI.</description><subject>Biological and medical sciences</subject><subject>Biopsy - adverse effects</subject><subject>Biopsy - methods</subject><subject>Birth Weight</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Preimplantation Diagnosis - adverse effects</subject><subject>Preimplantation Diagnosis - methods</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Sperm Injections, Intracytoplasmic - methods</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9LwzAYxvEgipvTo1fJRfRSl6Rtmhxl6hSGP0DPJU3fsEra1KRV9t_b0alHT8nhw_eFB6FTSq4okfF83dce2nkJPuZkD01pwknE4pTsoylhXESUcjpBRyG8EzJ8BT9EE8ZIIqSQU_TyCK5RnbLYOGvdV9S32BksZYq1awLovqs-wW5w4XyD9bqypYcGK9OBx1AXfuNwUbk2bIaAx8_Lm2N0YJQNcLJ7Z-jt7vZ1cR-tnpYPi-tVpBPGuyjjVGtgqQIjVaap4ipLhQbONBhBTZoRQmIwMUCmiqIkLCMiSZMYWFIyKuIZuhi7rXcfPYQur6ugwVrVgOtDLhnJJEuGyL-SMjpYGQ8yGqX2LgQPJm99VSu_ySnJt3Pn49z5OPfgz3blvqih_NU_-w7gfAdU0MoarxpdhT-Xyizh6dZdjs717T83vwEN0ZeU</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Desmyttere, S.</creator><creator>De Rycke, M.</creator><creator>Staessen, C.</creator><creator>Liebaers, I.</creator><creator>De Schrijver, F.</creator><creator>Verpoest, W.</creator><creator>Haentjens, P.</creator><creator>Bonduelle, Maryse</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201201</creationdate><title>Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD</title><author>Desmyttere, S. ; De Rycke, M. ; Staessen, C. ; Liebaers, I. ; De Schrijver, F. ; Verpoest, W. ; Haentjens, P. ; Bonduelle, Maryse</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-761cce25aef9a7c1a6a758ce62cef81f570003ef3ee7abbd027084543e24d2183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy - adverse effects</topic><topic>Biopsy - methods</topic><topic>Birth Weight</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Preimplantation Diagnosis - adverse effects</topic><topic>Preimplantation Diagnosis - methods</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Sperm Injections, Intracytoplasmic - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Desmyttere, S.</creatorcontrib><creatorcontrib>De Rycke, M.</creatorcontrib><creatorcontrib>Staessen, C.</creatorcontrib><creatorcontrib>Liebaers, I.</creatorcontrib><creatorcontrib>De Schrijver, F.</creatorcontrib><creatorcontrib>Verpoest, W.</creatorcontrib><creatorcontrib>Haentjens, P.</creatorcontrib><creatorcontrib>Bonduelle, Maryse</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Desmyttere, S.</au><au>De Rycke, M.</au><au>Staessen, C.</au><au>Liebaers, I.</au><au>De Schrijver, F.</au><au>Verpoest, W.</au><au>Haentjens, P.</au><au>Bonduelle, Maryse</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2012-01</date><risdate>2012</risdate><volume>27</volume><issue>1</issue><spage>288</spage><epage>293</epage><pages>288-293</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND
Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age.
METHODS
A prospective comparative follow-up study of children born after PGD and children born after ICSI by collecting written reports and performing a physical examination at 2 months was performed. Auxological data at birth and physical findings up to 2 months of age were compared for 995 children consecutively live born after embryo biopsy (1994–2009) and for a control group of 1507 children born after ICSI with embryo transfer on Day 5.
RESULTS
No differences regarding mean term, prematurity (term <32 w and <37 w), mean birthweight, very low birthweight (<1500 g), perinatal death, major malformations and neonatal hospitalizations in singletons and multiples born following PGD versus ICSI were observed. Compared with ICSI, fewer multiples born following PGD presented a low birthweight (<2500 g) (P = 0.005).
CONCLUSIONS
Embryo biopsy for PGD does not introduce extra risk to the overall medical condition of newborn children. Multiples born following embryo biopsy appear to be at lower risk for low birthweight compared with multiples born following ICSI.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>22048989</pmid><doi>10.1093/humrep/der360</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Biopsy - adverse effects Biopsy - methods Birth Weight Female Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Infant Infant, Newborn Male Medical sciences Multivariate Analysis Pregnancy Pregnancy Outcome Preimplantation Diagnosis - adverse effects Preimplantation Diagnosis - methods Prospective Studies Risk Sperm Injections, Intracytoplasmic - methods |
| title | Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD |
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