Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet

Highlights ► An accelerated development of grasping reflex was seen in mice offspring in the ‘MeHg + high DHA’ group when compared to ‘MeHg’ and ‘control’. ► DHA exposure led to a decrease in MeHg accumulation in brains of mice offspring ► Perinatal MeHg and DHA exposure induced transcriptional perturbations in murine brain and affected key functional classes of genes of biological relevance ► Identification of significantly differentially regulated gene clusters in response to the concomitant exposure of MeHg and DHA highlighted potential mechanisms of DHA amelioration of MeHg-induced toxicity.