Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family

Summary The role of epigenetic mechanisms in the regulation of microRNAs (miRNAs) with a tumour‐suppressor function in human neoplasms has recently been established. Several miRNAs have been found to be inappropriately regulated by DNA methylation in patients with acute lymphoblastic leukaemia (ALL)...

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Veröffentlicht in:	British journal of haematology 2011-10, Vol.155 (1), p.73-83
Hauptverfasser:	Rodriguez‐Otero, Paula, Román‐Gómez, José, Vilas‐Zornoza, Amaia, José‐Eneriz, Edurne San, Martín‐Palanco, Vanesa, Rifón, José, Torres, Antonio, Calasanz, María José, Agirre, Xabier, Prosper, Felipe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphatic leukemia acute lymphoblastic leukaemia Adolescent Adult Aged Aged, 80 and over Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences Cell proliferation Cell Proliferation - drug effects Child Child, Preschool Chromosome Aberrations CpG Islands - genetics Cyclin-Dependent Kinase 6 - antagonists & inhibitors Cyclin-Dependent Kinase 6 - biosynthesis Cyclin-Dependent Kinase 6 - genetics DNA Methylation DNA, Neoplasm - genetics Down-Regulation Epigenesis, Genetic epigenetics Female Fibroblast growth factor receptor 1 Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences microRNAs MicroRNAs - genetics MicroRNAs - physiology Middle Aged MIR9 miRNA Multivariate analysis oncogenic pathways Piperazines - pharmacology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Prognosis Pyridines - pharmacology Pyrimidines - pharmacology Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 1 - biosynthesis Receptor, Fibroblast Growth Factor, Type 1 - genetics RNA, Neoplasm - genetics RNA, Neoplasm - physiology Signal Transduction - drug effects Tumor Cells, Cultured Young Adult
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Zusammenfassung:	Summary The role of epigenetic mechanisms in the regulation of microRNAs (miRNAs) with a tumour‐suppressor function in human neoplasms has recently been established. Several miRNAs have been found to be inappropriately regulated by DNA methylation in patients with acute lymphoblastic leukaemia (ALL). We analysed the methylation status of the three members of the MIR9 family (MIR9‐1, MIR9‐2 and MIR9‐3) in a uniformly treated cohort of 200 newly diagnosed ALLs. MIR9 was methylated in 54% of the patients and was associated with downregulation of MIR9 (P
ISSN:	0007-1048 1365-2141
DOI:	10.1111/j.1365-2141.2011.08812.x