Blockade of NKG2D Synergized With CTLA4-Ig in Promoting Long-Term Graft Survival in Murine Models of Cardiac Transplantation

Blockade of B7-CD28 interaction with CTLA4-Ig could prolong allograft survival in cardiac transplantation. NKG2D is an activating or coactivating receptor on NK cells, γδ T, and CD8 T cells and played an important role in transplant immunity. C57BL/6 (wild type and γδ or interleukin (IL)-17) mice we...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation 2012-02, Vol.93 (4), p.356-363
Hauptverfasser:	Li, Jun, Zhu, Hongfei, Wang, Sihua, Ye, Ping, Liu, Chenggui, Wu, Jie, Xia, Jiahong
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animal models Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences CD8 antigen Cell Movement Cell survival CTLA-4 Antigen - drug effects CTLA-4 Antigen - immunology CTLA-4 protein Fundamental and applied biological sciences. Psychology Fundamental immunology gamma -Interferon Graft Survival - immunology Graft Survival - physiology Heart Heart Transplantation - immunology Heart Transplantation - pathology Heart Transplantation - physiology Immunoglobulin G - immunology Interleukin 17 Interleukin 4 Interleukin-17 - deficiency Interleukin-17 - genetics Lymphocytes T Macrophages Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Minor Histocompatibility Antigens - metabolism Models, Animal Monoclonal antibodies Muscle contraction Natural killer cells NK Cell Lectin-Like Receptor Subfamily K - drug effects NK Cell Lectin-Like Receptor Subfamily K - immunology NKG2 antigen Nuclear Matrix-Associated Proteins - metabolism Nucleocytoplasmic Transport Proteins - metabolism Receptors, Antigen, T-Cell, gamma-delta - deficiency Receptors, Antigen, T-Cell, gamma-delta - genetics Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart T-Lymphocytes - immunology T-Lymphocytes - pathology Tissue, organ and graft immunology Transplantation, Homologous
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Blockade of B7-CD28 interaction with CTLA4-Ig could prolong allograft survival in cardiac transplantation. NKG2D is an activating or coactivating receptor on NK cells, γδ T, and CD8 T cells and played an important role in transplant immunity. C57BL/6 (wild type and γδ or interleukin (IL)-17) mice were transplanted with allogeneic BALB/c hearts and treated with CTLA4-Ig alone or in combination with anti-NKG2D monoclonal antibodies. The survival of grafts was monitored daily by abdominal palpation until the complete cessation of cardiac contractility. We found that wild type recipient treated with anti-NKG2D monoclonal antibodies plus CTLA4-Ig showed significantly prolonged survival cardiac allograft (>90 days, P
ISSN:	0041-1337 1534-6080
DOI:	10.1097/TP.0b013e31823ffce7