Allopregnanolone prevents memory impairment: Effect on mRNA expression and enzymatic activity of hippocampal 3-α hydroxysteroid oxide-reductase

Allopregnanolone prevents memory impairment: Effect on mRNA expression and enzymatic activity of hippocampal 3-α hydroxysteroid oxide-reductase

Highlights ► Oestrogen and progesterone administration produces amnesic effect on OVX rats. ► Allopregnanolone has promnesic effect on OVX-EP rats. ► Allopregnanolone affect enzymatic activity of 3α-HOR in a memory task in female rats. ► Allo has a neuromodulatory effect on learning and memory proce...

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Veröffentlicht in:Brain research bulletin 2012-02, Vol.87 (2), p.280-285
Hauptverfasser: Escudero, Carla, Casas, Sebastián, Giuliani, Fernando, Bazzocchini, Vanesa, García, Sebastián, Yunes, Roberto, Cabrera, Ricardo
Format: Artikel
Sprache:eng
Schlagworte:
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - genetics
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - metabolism
3α-HOR
3α-HSD
Allopregnanolone
Analysis of Variance
Animals
Avoidance Learning - drug effects
Disease Models, Animal
Drug Administration Schedule
Estradiol - toxicity
Exploratory Behavior - drug effects
Female
Gene Expression Regulation, Enzymologic - drug effects
Hippocampus - drug effects
Hippocampus - enzymology
Inhibition (Psychology)
Memory
Memory Disorders - chemically induced
Memory Disorders - pathology
Memory Disorders - physiopathology
Memory Disorders - prevention & control
Motor Activity - drug effects
Neurology
Oestrogen
Ovariectomy
Pregnanolone - therapeutic use
Progesterone
Progesterone - toxicity
Rats
Rats, Sprague-Dawley
RNA, Messenger - metabolism
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Beschreibung
Zusammenfassung:Highlights ► Oestrogen and progesterone administration produces amnesic effect on OVX rats. ► Allopregnanolone has promnesic effect on OVX-EP rats. ► Allopregnanolone affect enzymatic activity of 3α-HOR in a memory task in female rats. ► Allo has a neuromodulatory effect on learning and memory processes.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.11.019