Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion

Highlights ► Intravenous administration of CDP-choline induces c-Fos expression in SON and PVN neurons. ► The number of activated (c-Fos-positive) oxytocin and vasopressin neurons increases with the increasing doses of CDP-choline. ► CDP-choline administration causes an increase on plasma oxytocin a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2012-02, Vol.87 (2), p.286-294
Hauptverfasser:	Eyigor, Ozhan, Coskun, Cenk, Cavun, Sinan, Savci, Vahide
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals c-Fos Citicoline Cytidine Diphosphate Choline - pharmacology Dose-Response Relationship, Drug Gene Expression Regulation - drug effects Hypothalamus Injections, Intravenous Male Neurology Neurons - drug effects Neurons - metabolism Nootropic Agents - pharmacology Oxytocin Oxytocin - metabolism Paraventricular Hypothalamic Nucleus - cytology Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Wistar Supraoptic Nucleus - cytology Time Factors Vasopressin Vasopressins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Intravenous administration of CDP-choline induces c-Fos expression in SON and PVN neurons. ► The number of activated (c-Fos-positive) oxytocin and vasopressin neurons increases with the increasing doses of CDP-choline. ► CDP-choline administration causes an increase on plasma oxytocin and vasopressin levels with a dose- and time-dependent manner.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2011.11.013