Further improvement of orally disintegrating tablets using micronized ethylcellulose

The aim of this study is to design a new orally disintegrating tablet (ODT) containing micronized ethylcellulose (MEC). The new ODT was prepared by physical mixing of rapidly disintegrating granules (RDGs) with MEC. To obtain RDGs, mannitol was spray-coated with a suspension of corn starch and crosp...

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Veröffentlicht in:	International journal of pharmaceutics 2012-02, Vol.423 (2), p.351-359
Hauptverfasser:	Okuda, Yutaka, Irisawa, Yosuke, Okimoto, Kazuto, Osawa, Takashi, Yamashita, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Oral Capillary channels Cellulose - analogs & derivatives Cellulose - chemistry Chemistry, Pharmaceutical Drug Compounding Excipients - chemistry Hardness Hardness Tests Humidity Kinetics Mannitol - chemistry Micronized ethylcellulose Models, Chemical Orally disintegrating tablet Physical strength Povidone - chemistry Solubility Starch - chemistry Suspension spray-coating method Tablets Technology, Pharmaceutical - methods Tomography, X-Ray Computed Water - chemistry Wettability Wicking action
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