Further improvement of orally disintegrating tablets using micronized ethylcellulose

Further improvement of orally disintegrating tablets using micronized ethylcellulose

The aim of this study is to design a new orally disintegrating tablet (ODT) containing micronized ethylcellulose (MEC). The new ODT was prepared by physical mixing of rapidly disintegrating granules (RDGs) with MEC. To obtain RDGs, mannitol was spray-coated with a suspension of corn starch and crosp...

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Veröffentlicht in:International journal of pharmaceutics 2012-02, Vol.423 (2), p.351-359
Hauptverfasser: Okuda, Yutaka, Irisawa, Yosuke, Okimoto, Kazuto, Osawa, Takashi, Yamashita, Shinji
Format: Artikel
Sprache:eng
Schlagworte:
Absorption
Administration, Oral
Capillary channels
Cellulose - analogs & derivatives
Cellulose - chemistry
Chemistry, Pharmaceutical
Drug Compounding
Excipients - chemistry
Hardness
Hardness Tests
Humidity
Kinetics
Mannitol - chemistry
Micronized ethylcellulose
Models, Chemical
Orally disintegrating tablet
Physical strength
Povidone - chemistry
Solubility
Starch - chemistry
Suspension spray-coating method
Tablets
Technology, Pharmaceutical - methods
Tomography, X-Ray Computed
Water - chemistry
Wettability
Wicking action
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Beschreibung
Zusammenfassung:The aim of this study is to design a new orally disintegrating tablet (ODT) containing micronized ethylcellulose (MEC). The new ODT was prepared by physical mixing of rapidly disintegrating granules (RDGs) with MEC. To obtain RDGs, mannitol was spray-coated with a suspension of corn starch and crospovidone (9:1, w/w ratio) using a fluidized-bed granulator (suspension spray-coating method). The new ODTs were evaluated for their hardness, friability, thickness, internal structure (X-ray-CT scanning), in vivo disintegration time, and water absorption rate. Since MEC increases tablet hardness by increasing the contact frequency between the granules, the new ODTs could obtain high hardness (>50N) and low friability (
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2011.10.050