Finding a Target for Resveratrol

Finding a Target for Resveratrol

Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of ev...

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Veröffentlicht in:Cell 2012-02, Vol.148 (3), p.387-389
Hauptverfasser: Tennen, Ruth I., Michishita-Kioi, Eriko, Chua, Katrin F.
Format: Artikel
Sprache:eng
Schlagworte:
enzyme inhibitors
mechanism of action
medicinal properties
resveratrol
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Zusammenfassung:Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1α.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.01.032