Respiratory control and sternohyoid muscle structure and function in aged male rats: Decreased susceptibility to chronic intermittent hypoxia

Highlights ► Chronic intermittent hypoxia (CIH) has no effect on baseline ventilation or ventilatory responses to acute hypoxia or hypercapnia. ► Sternohyoid (upper airway dilator) muscle myosin heavy chain fibre type and size, succinate dehydrogenase and glycerol-3-phosphate dehydrogenase enzyme ac...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2012-03, Vol.180 (2), p.175-182
Hauptverfasser:	Skelly, J. Richard, Edge, Deirdre, Shortt, Christine M, Jones, James F.X, Bradford, Aidan, O’Halloran, Ken D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Body Weight - physiology Chronic Disease Control of breathing Data Interpretation, Statistical Electric Stimulation Fibre type Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Heart - anatomy & histology Heart - physiology Hematocrit Hypoxia Hypoxia - physiopathology Immunohistochemistry Isometric Contraction - physiology Male Medical Education Muscle Contraction - physiology Muscle Fatigue - physiology Myosin Heavy Chains - metabolism Obstructive sleep apnoea syndrome Organ Size - physiology Oxygen Consumption - physiology Pharyngeal Muscles - anatomy & histology Pharyngeal Muscles - growth & development Pharyngeal Muscles - physiology Plethysmography, Whole Body Pulmonary/Respiratory Rats Rats, Wistar Respiratory Mechanics - physiology Sternohyoid muscle Succinate Dehydrogenase - metabolism
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Zusammenfassung:	Highlights ► Chronic intermittent hypoxia (CIH) has no effect on baseline ventilation or ventilatory responses to acute hypoxia or hypercapnia. ► Sternohyoid (upper airway dilator) muscle myosin heavy chain fibre type and size, succinate dehydrogenase and glycerol-3-phosphate dehydrogenase enzyme activities are unaffected by CIH. ► CIH does not alter aged sternohyoid muscle force or fatigue.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2011.11.004