Inspiratory-activated and inspiratory-inhibited airway vagal preganglionic neurons in the ventrolateral medulla of neonatal rat are different in intrinsic electrophysiological properties

Highlights ► Inspiratory-activated and inspiratory-inhibited AVPNs differ in architecture. ► Inspiratory-inhibited AVPNs has higher excitability under current clamp. ► Different K+ channels mediate the afterhyperpolarization in AVPNs. ► Different K+ channels mediate the voltage-gated lasting K+ curr...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2012-03, Vol.180 (2), p.323-330
Hauptverfasser:	Chen, Yonghua, Hou, Lili, Zhou, Xujiao, Qiu, Dongying, Yuan, Wenjun, Zhu, Lei, Wang, Jijiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Afterhyperpolarization Airway Animals Animals, Newborn Apamin Apamin - pharmacology Autonomic Fibers, Preganglionic - drug effects Autonomic Fibers, Preganglionic - physiology Brain Stem - physiology Charybdotoxin Charybdotoxin - pharmacology Depolarization Electrophysiological Phenomena Fluorescent Dyes Hypoglossal Nerve - physiology In Vitro Techniques Ion channel Ion channels Medical Education Medulla oblongata Medulla Oblongata - cytology Medulla Oblongata - drug effects Medulla Oblongata - physiology Membrane potential Neonates Nervous system Neurons nucleus ambiguus Patch clamp Patch-Clamp Techniques Potassium Channel Blockers - pharmacology Potassium channels (calcium-gated) Potassium Channels, Calcium-Activated - drug effects Potassium Channels, Calcium-Activated - physiology Potassium currents Preganglionic autonomic neurons Pulmonary/Respiratory Rats Respiratory Mechanics - physiology Respiratory tract Sodium currents Synapses - drug effects Synapses - physiology Trachea - innervation Trachea - physiology Vagus nerve Vagus Nerve - drug effects Vagus Nerve - physiology
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Beschreibung
Zusammenfassung:	Highlights ► Inspiratory-activated and inspiratory-inhibited AVPNs differ in architecture. ► Inspiratory-inhibited AVPNs has higher excitability under current clamp. ► Different K+ channels mediate the afterhyperpolarization in AVPNs. ► Different K+ channels mediate the voltage-gated lasting K+ currents in AVPNs.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2011.12.014