Efficient synthesis of multicyclic spirooxindoles via a cascade Michael/Michael/oxa-Michael reaction of curcumins and isatylidene malononitriles

A cascade Michael/Michael/oxa-Michael reaction between curcumins and isatylidene malononitriles has been developed. Multicyclic spirooxindoles were prepared in excellent yields and diastereoselectivities. DMAP was found to catalyze this transformation efficiently under mild reaction conditions.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2012-02, Vol.10 (8), p.1506-1509
Hauptverfasser:	Yin, Xiao-Gang, Liu, Xin-Yun, Hu, Zhi-Peng, Yan, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Curcumin - chemistry Heterocyclic Compounds - chemical synthesis Indoles - chemistry Models, Molecular Molecular Structure Nitriles - chemistry Spiro Compounds - chemical synthesis
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Beschreibung
Zusammenfassung:	A cascade Michael/Michael/oxa-Michael reaction between curcumins and isatylidene malononitriles has been developed. Multicyclic spirooxindoles were prepared in excellent yields and diastereoselectivities. DMAP was found to catalyze this transformation efficiently under mild reaction conditions.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c2ob06995d