A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotide phosphoramidites

A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotide phosphoramidites

Herein we report a convenient approach for the preparation of fully protected trinucleotide synthons to be used for the synthesis of gene libraries. The trinucleotide synthons bear β-cyanoethyl groups at the phosphate residues, and thus can be used in standard oligonucleotide synthesis without addit...

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Veröffentlicht in:Organic & biomolecular chemistry 2012-02, Vol.10 (8), p.1510-1513
Hauptverfasser: Janczyk, Matthäus, Appel, Bettina, Springstubbe, Danilo, Fritz, Hans-Joachim, Müller, Sabine
Format: Artikel
Sprache:eng
Schlagworte:
Cyanates - chemistry
Molecular Structure
Oligonucleotides - chemistry
Organophosphorus Compounds - chemistry
Phosphorylation
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Zusammenfassung:Herein we report a convenient approach for the preparation of fully protected trinucleotide synthons to be used for the synthesis of gene libraries. The trinucleotide synthons bear β-cyanoethyl groups at the phosphate residues, and thus can be used in standard oligonucleotide synthesis without additional steps for deprotection and work-up.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob06934b