Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003–2009

Highlights ► We reviewed South African laboratory-confirmed Hib disease among children. ► Half of invasive Hib disease was classified as vaccine failures. ► More than half of these vaccine failures were in children older than 18 months. ► Just more than half of these vaccine failures occurred in HIV...

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Veröffentlicht in:	Vaccine 2012-01, Vol.30 (3), p.565-571
Hauptverfasser:	von Gottberg, Anne, Cohen, Cheryl, Whitelaw, Andrew, Chhagan, Meera, Flannery, Brendan, Cohen, Adam L, de Gouveia, Linda, Plessis, Mignon du, Madhi, Shabir A, Klugman, Keith P
Format:	Artikel
Sprache:	eng
Schlagworte:	Africans Allergy and Immunology Bacterial meningitis Child, Preschool children Children & youth Haemophilus Infections - epidemiology Haemophilus Infections - immunology Haemophilus Infections - microbiology Haemophilus Infections - prevention & control Haemophilus influenzae Haemophilus influenzae serotype b Haemophilus influenzae type b - immunology Haemophilus influenzae type b - isolation & purification Haemophilus Vaccines - administration & dosage Haemophilus Vaccines - immunology Hib HIV HIV infections Human immunodeficiency virus Humans Infant Infant, Newborn Laboratories Laboratory-based surveillance Male Meningitis monitoring patients serotypes South Africa - epidemiology vaccination Vaccination - methods Vaccination - utilization Vaccine Vaccines
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Beschreibung
Zusammenfassung:	Highlights ► We reviewed South African laboratory-confirmed Hib disease among children. ► Half of invasive Hib disease was classified as vaccine failures. ► More than half of these vaccine failures were in children older than 18 months. ► Just more than half of these vaccine failures occurred in HIV-uninfected children. ► Additional doses of Hib vaccine in routine programs needs further investigation.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.11.066