Composite polymer particles with stimuli-responsive surface properties and specific activity of adsorbed/released trypsin

Composite polymer particles with stimuli-responsive surface properties and specific activity of adsorbed/released trypsin

Micron-sized monodispersed stimuli-responsive polys' (PS)/poly(2-dimethylaminoethyl methacrylate-N-isopropyl acrylamide-ethylene glycol dimethacrylate) [P(DM-NIPAM-EGDM)] composite polymer particles were prepared by seeded copolymerisation of DM, NIPAM and EGDM with PS seed particles. Adsorptio...

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Veröffentlicht in:Colloid and polymer science 2007-03, Vol.285 (6), p.715-720
Hauptverfasser: ASHRAFUL ALAM, M, JALIL MIAH, M. A, AHMAD, Hasan
Format: Artikel
Sprache:eng
Schlagworte:
Adsorption
Applied sciences
Atoms & subatomic particles
Copolymerization
Exact sciences and technology
Forms of application and semi-finished materials
Glycol dimethacrylates
Miscellaneous
Particulate composites
Polymer industry, paints, wood
Polymers
Polystyrene resins
Surface chemistry
Surface properties
Technology of polymers
Trypsin
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Zusammenfassung:Micron-sized monodispersed stimuli-responsive polys' (PS)/poly(2-dimethylaminoethyl methacrylate-N-isopropyl acrylamide-ethylene glycol dimethacrylate) [P(DM-NIPAM-EGDM)] composite polymer particles were prepared by seeded copolymerisation of DM, NIPAM and EGDM with PS seed particles. Adsorption behaviour of trypsin suggested that composite particles surface has both temperature- and pH-responsive swelling-deswelling characteristics. The performance of composite polymer particles as a carrier for biomolecules in adsorption/release experiments was evaluated by measuring the specific activities of adsorbed trypsin as a function of temperature and pH.[PUBLICATION ABSTRACT]
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-006-1638-9