Rambutan rind in the management of hyperglycemia
Plant extracts have been suggested as a rich as yet unexplored source of potentially useful anti-diabetic drugs. Recent scientific investigations have confirmed the efficacy of many of these preparations, as effective antioxidants; able to regenerate functional pancreatic beta cells and has a hypogl...
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Veröffentlicht in: | Food research international 2011-08, Vol.44 (7), p.2278-2282 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Plant extracts have been suggested as a rich as yet unexplored source of potentially useful anti-diabetic drugs. Recent scientific investigations have confirmed the efficacy of many of these preparations, as effective antioxidants; able to regenerate functional pancreatic beta cells and has a hypoglycemic potential. In this study, the exotic rambutan (Nephelium lappaceum L.) fruit's rind has been shown to be effective in inhibiting the carbohydrate hydrolyzing enzymes, alpha glucosidase (EC50=2.7μg/mL) and alpha amylase (EC50=70.8μg/mL), at a much more significant level than the drug acarbose (EC50=3500μg/mL; alpha glucosidase; EC50=12μg/mL; alpha amylase). In addition, the geraniin-enriched ethanolic extracts were able to inhibit the key enzyme in the polyol pathway, aldol reductase (EC50=0.04μg/mL) and prevent the formation of advanced glycation end-products (AGE) by 43%. These findings indicate that the geraniin-standardized N. lappaceum rind may be a potential source of an anti-hyperglycemic agent. |
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ISSN: | 0963-9969 1873-7145 |
DOI: | 10.1016/j.foodres.2011.01.048 |