Models of Visceral Pain: Colorectal Distension (CRD)

Models of Visceral Pain: Colorectal Distension (CRD)

The visceromotor response to balloon distension of the colon is a robust behavioral model of visceral nociception in rodents and is ideally suited for studying the visceral antinociceptive activity of drugs. This unit describes, in detail, quantification of this response with the use of electromyogr...

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Veröffentlicht in:Current Protocols in Pharmacology 2004-09, Vol.25 (1), p.5.36.1-5.36.17
Hauptverfasser: Jones, R. Carter W., Gebhart, G.F.
Format: Artikel
Sprache:eng
Schlagworte:
Abdominal Muscles - physiology
Animals
Balloon
Catheterization - methods
Colon
Colon - physiology
Dilatation, Pathologic - physiopathology
Disease Models, Animal
Electrodes, Implanted
Electromyography
Electromyography - instrumentation
Mice
Mouse
Rat
Rats
Rectum - physiology
Specimen Handling
Visceral Pain - etiology
Visceral Pain - physiopathology
Visceromotor
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Beschreibung
Zusammenfassung:The visceromotor response to balloon distension of the colon is a robust behavioral model of visceral nociception in rodents and is ideally suited for studying the visceral antinociceptive activity of drugs. This unit describes, in detail, quantification of this response with the use of electromyography in both rats and mice.
ISSN:1934-8282
1934-8290
DOI:10.1002/0471141755.ph0536s25