Utility of diffusion-weighted imaging in the evaluation of liver fibrosis
Objectives To evaluate the usefulness of diffusion- weighted MRI (DWI) in the detection and staging of liver fibrosis and inflammation. Methods DWI was performed with b-factors of 0, 500 and 1000 s/mm². ADC values were obtained by placing circular regions of interest in four segments of the liver. D...
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| Veröffentlicht in: | European radiology 2012-03, Vol.22 (3), p.682-687 |
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| creator | Bakan, Ayse Ahsen Inci, Ercan Bakan, Selim Gokturk, Suut Cimilli, Tan |
| description | Objectives
To evaluate the usefulness of diffusion- weighted MRI (DWI) in the detection and staging of liver fibrosis and inflammation.
Methods
DWI was performed with b-factors of 0, 500 and 1000 s/mm². ADC values were obtained by placing circular regions of interest in four segments of the liver. Differences between the study (
n
= 34) and control groups’ (
n
= 25) ADC values were examined. Further, this study investigated if and how ADC values were related to fibrosis stages and histological activity index (HAI) scores.
Results
The mean ADC value of the liver was smaller in the study group compared with the control group (P |
| doi_str_mv | 10.1007/s00330-011-2295-z |
| format | Article |
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To evaluate the usefulness of diffusion- weighted MRI (DWI) in the detection and staging of liver fibrosis and inflammation.
Methods
DWI was performed with b-factors of 0, 500 and 1000 s/mm². ADC values were obtained by placing circular regions of interest in four segments of the liver. Differences between the study (
n
= 34) and control groups’ (
n
= 25) ADC values were examined. Further, this study investigated if and how ADC values were related to fibrosis stages and histological activity index (HAI) scores.
Results
The mean ADC value of the liver was smaller in the study group compared with the control group (P < 0.001). Spearman rho correlation analyses showed lower ADC values were associated with higher fibrosis and HAI scores (P < 0.01). There were statistically significant differences in liver ADC values between each combination of fibrosis stages (e.g. stages 0 and 1, 0 and 2) except for stages 1 and 2.
Conclusions
ADC values prove to be a valuable technique for the diagnosis of liver fibrosis and inflammation. They can also be useful in fibrosis staging, particularly in distinguishing later stages of fibrosis from intermediate and early stages.
Key Points
Diffusion Weighted MRI is a promising technique for diagnosis of liver fibrosis.
Apparent Diffusion Coefficients provide valuable information for staging of liver fibrosis.
DWI may offer alternative to biopsy for assessing liver fibrosis.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-011-2295-z</identifier><identifier>PMID: 21984447</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Abdomen ; Adult ; Analysis of Variance ; Biopsy ; Case-Control Studies ; Diagnostic Radiology ; Diffusion Magnetic Resonance Imaging - methods ; Female ; Hepatitis ; Histology ; Humans ; Image Interpretation, Computer-Assisted ; Imaging ; Inflammation ; Internal Medicine ; Interventional Radiology ; Liver ; Liver Cirrhosis - diagnosis ; Magnetic Resonance ; Magnetic resonance imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Radiology ; Retrospective Studies ; Ultrasound</subject><ispartof>European radiology, 2012-03, Vol.22 (3), p.682-687</ispartof><rights>European Society of Radiology 2011</rights><rights>European Society of Radiology 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-40aef8ccc3ab33ebd6cc8500333635b5450c91b8f56d7bd9244a78098ed021e63</citedby><cites>FETCH-LOGICAL-c437t-40aef8ccc3ab33ebd6cc8500333635b5450c91b8f56d7bd9244a78098ed021e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-011-2295-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-011-2295-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21984447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakan, Ayse Ahsen</creatorcontrib><creatorcontrib>Inci, Ercan</creatorcontrib><creatorcontrib>Bakan, Selim</creatorcontrib><creatorcontrib>Gokturk, Suut</creatorcontrib><creatorcontrib>Cimilli, Tan</creatorcontrib><title>Utility of diffusion-weighted imaging in the evaluation of liver fibrosis</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To evaluate the usefulness of diffusion- weighted MRI (DWI) in the detection and staging of liver fibrosis and inflammation.
Methods
DWI was performed with b-factors of 0, 500 and 1000 s/mm². ADC values were obtained by placing circular regions of interest in four segments of the liver. Differences between the study (
n
= 34) and control groups’ (
n
= 25) ADC values were examined. Further, this study investigated if and how ADC values were related to fibrosis stages and histological activity index (HAI) scores.
Results
The mean ADC value of the liver was smaller in the study group compared with the control group (P < 0.001). Spearman rho correlation analyses showed lower ADC values were associated with higher fibrosis and HAI scores (P < 0.01). There were statistically significant differences in liver ADC values between each combination of fibrosis stages (e.g. stages 0 and 1, 0 and 2) except for stages 1 and 2.
Conclusions
ADC values prove to be a valuable technique for the diagnosis of liver fibrosis and inflammation. They can also be useful in fibrosis staging, particularly in distinguishing later stages of fibrosis from intermediate and early stages.
Key Points
Diffusion Weighted MRI is a promising technique for diagnosis of liver fibrosis.
Apparent Diffusion Coefficients provide valuable information for staging of liver fibrosis.
DWI may offer alternative to biopsy for assessing liver fibrosis.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Diagnostic Radiology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Female</subject><subject>Hepatitis</subject><subject>Histology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Liver</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Magnetic Resonance</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kM9LwzAYhoMobk7_AC9S8OApml9tkqMMfwwGXtw5pGmyZXTtbNrJ9teb0ikieMrhe773y_sAcI3RPUaIPwSEKEUQYQwJkSk8nIAxZpRAjAQ7BWMkqYBcSjYCFyGsEUISM34ORgRLwRjjYzBbtL707T6pXVJ457rg6wp-Wr9ctbZI_EYvfbVMfJW0K5vYnS473Uak50u_s03ifN7UwYdLcOZ0GezV8Z2AxfPT-_QVzt9eZtPHOTSM8hYypK0Txhiqc0ptXmTGiLQvQjOa5ilLkZE4Fy7NCp4XkjCmuUBS2AIRbDM6AXdD7rapPzobWrXxwdiy1JWtu6AklhmTnPBI3v4h13XXVPFzCsesjEocDU0AHigTa4TGOrVtYu1mHyHVa1aDZhU1q16zOsSdm2Nyl29s8bPx7TUCZABCHFVL2_w-_V_qF7dUh8s</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Bakan, Ayse Ahsen</creator><creator>Inci, Ercan</creator><creator>Bakan, Selim</creator><creator>Gokturk, Suut</creator><creator>Cimilli, Tan</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Utility of diffusion-weighted imaging in the evaluation of liver fibrosis</title><author>Bakan, Ayse Ahsen ; Inci, Ercan ; Bakan, Selim ; Gokturk, Suut ; Cimilli, Tan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-40aef8ccc3ab33ebd6cc8500333635b5450c91b8f56d7bd9244a78098ed021e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biopsy</topic><topic>Case-Control Studies</topic><topic>Diagnostic Radiology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Female</topic><topic>Hepatitis</topic><topic>Histology</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Liver</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Magnetic Resonance</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakan, Ayse Ahsen</creatorcontrib><creatorcontrib>Inci, Ercan</creatorcontrib><creatorcontrib>Bakan, Selim</creatorcontrib><creatorcontrib>Gokturk, Suut</creatorcontrib><creatorcontrib>Cimilli, Tan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakan, Ayse Ahsen</au><au>Inci, Ercan</au><au>Bakan, Selim</au><au>Gokturk, Suut</au><au>Cimilli, Tan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of diffusion-weighted imaging in the evaluation of liver fibrosis</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>22</volume><issue>3</issue><spage>682</spage><epage>687</epage><pages>682-687</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To evaluate the usefulness of diffusion- weighted MRI (DWI) in the detection and staging of liver fibrosis and inflammation.
Methods
DWI was performed with b-factors of 0, 500 and 1000 s/mm². ADC values were obtained by placing circular regions of interest in four segments of the liver. Differences between the study (
n
= 34) and control groups’ (
n
= 25) ADC values were examined. Further, this study investigated if and how ADC values were related to fibrosis stages and histological activity index (HAI) scores.
Results
The mean ADC value of the liver was smaller in the study group compared with the control group (P < 0.001). Spearman rho correlation analyses showed lower ADC values were associated with higher fibrosis and HAI scores (P < 0.01). There were statistically significant differences in liver ADC values between each combination of fibrosis stages (e.g. stages 0 and 1, 0 and 2) except for stages 1 and 2.
Conclusions
ADC values prove to be a valuable technique for the diagnosis of liver fibrosis and inflammation. They can also be useful in fibrosis staging, particularly in distinguishing later stages of fibrosis from intermediate and early stages.
Key Points
Diffusion Weighted MRI is a promising technique for diagnosis of liver fibrosis.
Apparent Diffusion Coefficients provide valuable information for staging of liver fibrosis.
DWI may offer alternative to biopsy for assessing liver fibrosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21984447</pmid><doi>10.1007/s00330-011-2295-z</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2012-03, Vol.22 (3), p.682-687 |
| issn | 0938-7994 1432-1084 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdomen Adult Analysis of Variance Biopsy Case-Control Studies Diagnostic Radiology Diffusion Magnetic Resonance Imaging - methods Female Hepatitis Histology Humans Image Interpretation, Computer-Assisted Imaging Inflammation Internal Medicine Interventional Radiology Liver Liver Cirrhosis - diagnosis Magnetic Resonance Magnetic resonance imaging Male Medicine Medicine & Public Health Middle Aged Neuroradiology Radiology Retrospective Studies Ultrasound |
| title | Utility of diffusion-weighted imaging in the evaluation of liver fibrosis |
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