Utility of diffusion-weighted imaging in the evaluation of liver fibrosis

Utility of diffusion-weighted imaging in the evaluation of liver fibrosis

Objectives To evaluate the usefulness of diffusion- weighted MRI (DWI) in the detection and staging of liver fibrosis and inflammation. Methods DWI was performed with b-factors of 0, 500 and 1000 s/mm². ADC values were obtained by placing circular regions of interest in four segments of the liver. D...

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Veröffentlicht in:European radiology 2012-03, Vol.22 (3), p.682-687
Hauptverfasser: Bakan, Ayse Ahsen, Inci, Ercan, Bakan, Selim, Gokturk, Suut, Cimilli, Tan
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen
Adult
Analysis of Variance
Biopsy
Case-Control Studies
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging - methods
Female
Hepatitis
Histology
Humans
Image Interpretation, Computer-Assisted
Imaging
Inflammation
Internal Medicine
Interventional Radiology
Liver
Liver Cirrhosis - diagnosis
Magnetic Resonance
Magnetic resonance imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Radiology
Retrospective Studies
Ultrasound
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Zusammenfassung:Objectives To evaluate the usefulness of diffusion- weighted MRI (DWI) in the detection and staging of liver fibrosis and inflammation. Methods DWI was performed with b-factors of 0, 500 and 1000 s/mm². ADC values were obtained by placing circular regions of interest in four segments of the liver. Differences between the study ( n  = 34) and control groups’ ( n  = 25) ADC values were examined. Further, this study investigated if and how ADC values were related to fibrosis stages and histological activity index (HAI) scores. Results The mean ADC value of the liver was smaller in the study group compared with the control group (P 
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-011-2295-z