New Tricyclic Alkaloids, Cassiarins G, H, J, and K from Leaves of Cassia siamea

Four new alkaloids, cassiarins G, H, J, and K (1-4) which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from the leaves of Cassia siamea (Leguminosae) and the structures of 1-4 were elucidated by 1D- and 2D-NMR analysis and X-ray crystallographic analysis.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 2012/02/01, Vol.60(2), pp.219-222
Hauptverfasser:	Deguchi, Jun, Hirahara, Tomoe, Hirasawa, Yusuke, Ekasari, Wiwied, Widyawaruyanti, Aty, Shirota, Osamu, Shiro, Motoo, Morita, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloid Alkaloids - chemistry Animals Antimalarials - chemistry Antimalarials - pharmacology antiplasmodial activity Cassia - chemistry Cassia siamea cassiarin Crystallography, X-Ray Heterocyclic Compounds, 3-Ring - chemistry Heterocyclic Compounds, 3-Ring - pharmacology Magnetic Resonance Spectroscopy Molecular Structure Plant Leaves - chemistry Plasmodium falciparum - drug effects Plasmodium falciparum 3D7
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Beschreibung
Zusammenfassung:	Four new alkaloids, cassiarins G, H, J, and K (1-4) which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from the leaves of Cassia siamea (Leguminosae) and the structures of 1-4 were elucidated by 1D- and 2D-NMR analysis and X-ray crystallographic analysis.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.60.219