The tumor suppressor HACE1 targets Rac1 to ubiquitin-mediated proteasomal degradation
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Veröffentlicht in: | M.S. Médecine sciences 2012-01, Vol.28 (1), p.39-41 |
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creator | Gacon, Gérard Mettouchi, Amel Lemichez, Emmanuel |
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doi_str_mv | 10.1051/medsci/2012281014 |
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source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Aminoquinolines - pharmacology Aminoquinolines - therapeutic use Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bacterial Toxins - pharmacology Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Escherichia coli Proteins - pharmacology Genes, Tumor Suppressor Humans Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Mice Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - physiology Neoplasms - genetics Neoplasms - metabolism Neuropeptides - antagonists & inhibitors Neuropeptides - physiology Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational Pyrimidines - pharmacology Pyrimidines - therapeutic use rac GTP-Binding Proteins - antagonists & inhibitors rac GTP-Binding Proteins - physiology rac1 GTP-Binding Protein - metabolism rho GTP-Binding Proteins - metabolism RNA Interference Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - physiology Ubiquitin - metabolism Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - physiology Ubiquitination Wilms Tumor - genetics Wilms Tumor - metabolism |
title | The tumor suppressor HACE1 targets Rac1 to ubiquitin-mediated proteasomal degradation |
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