The tumor suppressor HACE1 targets Rac1 to ubiquitin-mediated proteasomal degradation

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Veröffentlicht in:	M.S. Médecine sciences 2012-01, Vol.28 (1), p.39-41
Hauptverfasser:	Gacon, Gérard, Mettouchi, Amel, Lemichez, Emmanuel
Format:	Artikel
Sprache:	fre
Schlagworte:	Aminoquinolines - pharmacology Aminoquinolines - therapeutic use Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bacterial Toxins - pharmacology Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Escherichia coli Proteins - pharmacology Genes, Tumor Suppressor Humans Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Mice Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - physiology Neoplasms - genetics Neoplasms - metabolism Neuropeptides - antagonists & inhibitors Neuropeptides - physiology Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational Pyrimidines - pharmacology Pyrimidines - therapeutic use rac GTP-Binding Proteins - antagonists & inhibitors rac GTP-Binding Proteins - physiology rac1 GTP-Binding Protein - metabolism rho GTP-Binding Proteins - metabolism RNA Interference Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - physiology Ubiquitin - metabolism Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - physiology Ubiquitination Wilms Tumor - genetics Wilms Tumor - metabolism
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ISSN:	0767-0974
DOI:	10.1051/medsci/2012281014