Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population
Abstract We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992,...
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| Veröffentlicht in: | Diabetes research and clinical practice 2012-02, Vol.95 (2), p.e37-e40 |
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| container_title | Diabetes research and clinical practice |
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| creator | Nemr, Rita Almawi, Ahmad W Echtay, Akram Sater, Mai S Daher, Hoda S Almawi, Wassim Y |
| description | Abstract We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese. |
| doi_str_mv | 10.1016/j.diabres.2011.11.002 |
| format | Article |
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Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2011.11.002</identifier><identifier>PMID: 22119613</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Arabs - genetics ; CDKAL1 ; CDKN2A/2B ; Cyclin-Dependent Kinase 5 - genetics ; Cyclin-Dependent Kinase Inhibitor p15 - genetics ; Cyclin-Dependent Kinase Inhibitor p16 - genetics ; Diabetes ; Diabetes Mellitus, Type 2 - genetics ; Endocrinology & Metabolism ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Haplotypes ; Humans ; Lebanon - epidemiology ; Polymorphism, Single Nucleotide ; Replication studies ; Transcription Factors ; tRNA Methyltransferases</subject><ispartof>Diabetes research and clinical practice, 2012-02, Vol.95 (2), p.e37-e40</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. 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Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese.</description><subject>Arabs - genetics</subject><subject>CDKAL1</subject><subject>CDKN2A/2B</subject><subject>Cyclin-Dependent Kinase 5 - genetics</subject><subject>Cyclin-Dependent Kinase Inhibitor p15 - genetics</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - genetics</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Endocrinology & Metabolism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Lebanon - epidemiology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Replication studies</subject><subject>Transcription Factors</subject><subject>tRNA Methyltransferases</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU2P0zAQtRCI7S78BJBvnNr1TJo0voBKYQFRgcTH2bKdCbikcdZ2FvXCb8dpCwcuSCN5Rnpv3vg9xp6AWICA6nq3aJw2geICBcAilxB4j82gXuG8RlzdZ7OMq4_9BbuMcSeEqIpl-ZBdIALICooZ-_WJhs5ZnZzveUxjc-C-5dbv93m-08HpPkXuer559X69Ba77Zmo_4PoaX_Jv1FPkOkZvnU7U8J8ufefpMBBHPt1HiY7sLRmdocTXQRs--GHsjpKP2INWd5Een98r9vXm9ZfN2_n245t3m_V2bpcg05xQGLQGpZRQoyxtU0pDNVispG5rW4DBFoUsaNm0tZCNrY0oTGlo2a6sEMUVe3baOwR_O1JMau-ipa7LV_kxKgkSsQLEjCxPSBt8jIFaNQS31-GgQKjJebVTZ-fV5LzKlZ3PvKdnhdHsqfnL-mN1Brw4ASj_885RUNE66i01LpBNqvHuvxLP_9lgO9fn8LofdKC482Pos4kKVEQl1Ocp_il9gBw8QFn8BvRTq1A</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Nemr, Rita</creator><creator>Almawi, Ahmad W</creator><creator>Echtay, Akram</creator><creator>Sater, Mai S</creator><creator>Daher, Hoda S</creator><creator>Almawi, Wassim Y</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population</title><author>Nemr, Rita ; Almawi, Ahmad W ; Echtay, Akram ; Sater, Mai S ; Daher, Hoda S ; Almawi, Wassim Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-e20b2cb299918295cd59be81c269af8c31b2f2093e4df809dc8b03b5be4f7c003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Arabs - genetics</topic><topic>CDKAL1</topic><topic>CDKN2A/2B</topic><topic>Cyclin-Dependent Kinase 5 - genetics</topic><topic>Cyclin-Dependent Kinase Inhibitor p15 - genetics</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - genetics</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Endocrinology & Metabolism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-Wide Association Study</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Lebanon - epidemiology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Replication studies</topic><topic>Transcription Factors</topic><topic>tRNA Methyltransferases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nemr, Rita</creatorcontrib><creatorcontrib>Almawi, Ahmad W</creatorcontrib><creatorcontrib>Echtay, Akram</creatorcontrib><creatorcontrib>Sater, Mai S</creatorcontrib><creatorcontrib>Daher, Hoda S</creatorcontrib><creatorcontrib>Almawi, Wassim Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nemr, Rita</au><au>Almawi, Ahmad W</au><au>Echtay, Akram</au><au>Sater, Mai S</au><au>Daher, Hoda S</au><au>Almawi, Wassim Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>95</volume><issue>2</issue><spage>e37</spage><epage>e40</epage><pages>e37-e40</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22119613</pmid><doi>10.1016/j.diabres.2011.11.002</doi></addata></record> |
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| identifier | ISSN: 0168-8227 |
| ispartof | Diabetes research and clinical practice, 2012-02, Vol.95 (2), p.e37-e40 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Arabs - genetics CDKAL1 CDKN2A/2B Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics Diabetes Diabetes Mellitus, Type 2 - genetics Endocrinology & Metabolism Genetic Predisposition to Disease Genome-Wide Association Study Haplotypes Humans Lebanon - epidemiology Polymorphism, Single Nucleotide Replication studies Transcription Factors tRNA Methyltransferases |
| title | Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population |
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